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Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.
[Yang, Xian-Wen; Steinmetz, Andre; Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg; Yang, Bing; Zhou, Xue-Feng; Liu, Yong-Hong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Gai-Yun; Ying, Jian-Xi] State Ocean Adm, Key Lab Marine Biogenet Resources, Inst Oceanog 3, Xiamen 361005, Peoples R China; xianwen.yang@crp-sante.lu; zhgyun2008@yahoo.com.cn; yingjianxiah@126.com; bingo525@163.com; xfzhou@scsio.ac.cn; andre.steinmetz@crp-sante.lu; yonghongliu@scsio.ac.cn; ning.wang@crp-sante.lu
2013
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume11Issue:1Pages:33-39
AbstractOne new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 mu g/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).
DepartmentLMB
KeywordDeep-sea Sediment Actinomycete Serinicoccus Profundi Sp Nov. Alkaloid Antibacterial Activity Cytotoxicity
Subject AreaChemistry, Medicinal
Funding OrganizationThis study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). ; This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). ; This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). ; This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022).
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Language英语
Funding OrganizationThis study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). ; This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). ; This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). ; This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022).
WOS IDWOS:000314040300003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11082
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorxianwen.yang@crp-sante.lu; zhgyun2008@yahoo.com.cn; yingjianxiah@126.com; bingo525@163.com; xfzhou@scsio.ac.cn; andre.steinmetz@crp-sante.lu; yonghongliu@scsio.ac.cn; ning.wang@crp-sante.lu
Recommended Citation
GB/T 7714
[Yang, Xian-Wen,Steinmetz, Andre,Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg,et al. Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.[J]. MARINE DRUGS,2013,11(1):33-39.
APA [Yang, Xian-Wen.,Steinmetz, Andre.,Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg.,Yang, Bing.,Zhou, Xue-Feng.,...&ning.wang@crp-sante.lu.(2013).Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov..MARINE DRUGS,11(1),33-39.
MLA [Yang, Xian-Wen,et al."Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.".MARINE DRUGS 11.1(2013):33-39.
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