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学科主题: Chemistry, Medicinal
题名: Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.
作者: [Yang, Xian-Wen ; Steinmetz, Andre ; Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg ; [Yang, Xian-Wen ; Yang, Bing ; Zhou, Xue-Feng ; Liu, Yong-Hong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China ; [Zhang, Gai-Yun ; Ying, Jian-Xi] State Ocean Adm, Key Lab Marine Biogenet Resources, Inst Oceanog 3, Xiamen 361005, Peoples R China
通讯作者: xianwen.yang@crp-sante.lu ; zhgyun2008@yahoo.com.cn ; yingjianxiah@126.com ; bingo525@163.com ; xfzhou@scsio.ac.cn ; andre.steinmetz@crp-sante.lu ; yonghongliu@scsio.ac.cn ; ning.wang@crp-sante.lu
关键词: deep-sea sediment ; actinomycete ; Serinicoccus profundi sp nov. ; alkaloid ; antibacterial activity ; cytotoxicity
刊名: MARINE DRUGS
发表日期: 2013
卷: 11, 期:1, 页:33-39
部门归属: LMB
资助者: This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022).
摘要: One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 mu g/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000314040300003
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11082
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Yang, Xian-Wen; Steinmetz, Andre; Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg; [Yang, Xian-Wen; Yang, Bing; Zhou, Xue-Feng; Liu, Yong-Hong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Gai-Yun; Ying, Jian-Xi] State Ocean Adm, Key Lab Marine Biogenet Resources, Inst Oceanog 3, Xiamen 361005, Peoples R China.Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.,MARINE DRUGS,2013,11(1):33-39
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文件名: Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov..pdf
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