New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039
[Zhang, Qingbo; Li, Sumei; Tian, Xinpeng; Zhang, Haibo; Zhang, Guangtao; Zhu, Yiguang; Zhang, Si; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol,RNAM Ctr Marine Microbio, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Qingbo] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R China; czhang2006@gmail.com
2013
发表期刊JOURNAL OF ANTIBIOTICS
ISSN0021-8820
卷号66期号:1页码:31-36
摘要The strain SCSIO 03039 was isolated from a sediment sample in the Indian Ocean and was characterized as a Nocardiopsis alba species on the basis of its 16S rRNA gene sequence. Seven diketopiperazines (DKPs), including two new DKPs nocazines D (2a) and E (2b), and five known DKPs (1, 3-6), were isolated from N. alba SCSIO 03039, along with two known compounds 2-methoxy-1,4-naphthoquinone (7) and 1-hydroxy-4-methoxy-2-naphthoic acid (8). Their structures were elucidated by mass and NMR spectroscopic analyses. The structure of methoxyneihumicin (1), previously proposed in a conference poster lacking publicly available experimental data, was validated for the first time by detailed NMR analyses and X-ray diffraction study. The two enantiomers nocazines D (2a) and E (2b) were isolated as a mixture. Compounds 3 and 4 were only known as synthetic compounds before. Methoxyneihumicin (1) exhibited in vitro cytotoxicities against MCF-7 and SF-268 with IC50 values of 4.6 and 12.7 mu M, respectively, better than those of 6 (22.0 and 20.6 mu M). The other compounds showed less pronounced cytotoxities against three tested human cancer cell lines and no compounds displayed antibacterial activities toward four indicator strains. The Journal of Antibiotics (2013) 66, 31-36; doi: 10.1038/ja.2012.88; published online 24 October 2012
部门归属LMB
关键词Cytotoxicity Deep-sea Diketopiperazines Marine Actinomycetes Nocardiopsis
学科领域Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
资助者This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology. ; This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology. ; This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology. ; This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology.
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语种英语
资助者This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology. ; This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology. ; This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology. ; This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology.
WOS记录号WOS:000314165300005
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11083
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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[Zhang, Qingbo,Li, Sumei,Tian, Xinpeng,et al. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039[J]. JOURNAL OF ANTIBIOTICS,2013,66(1):31-36.
APA [Zhang, Qingbo.,Li, Sumei.,Tian, Xinpeng.,Zhang, Haibo.,Zhang, Guangtao.,...&czhang2006@gmail.com.(2013).New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039.JOURNAL OF ANTIBIOTICS,66(1),31-36.
MLA [Zhang, Qingbo,et al."New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039".JOURNAL OF ANTIBIOTICS 66.1(2013):31-36.
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