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学科主题: Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
题名: New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039
作者: [Zhang, Qingbo ; Li, Sumei ; Tian, Xinpeng ; Zhang, Haibo ; Zhang, Guangtao ; Zhu, Yiguang ; Zhang, Si ; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol,RNAM Ctr Marine Microbio, Guangzhou 510301, Guangdong, Peoples R China ; [Zhang, Qingbo] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China ; [Chen, Yuchan ; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R China
通讯作者: czhang2006@gmail.com
关键词: cytotoxicity ; deep-sea ; diketopiperazines ; marine actinomycetes ; Nocardiopsis
刊名: JOURNAL OF ANTIBIOTICS
发表日期: 2013
卷: 66, 期:1, 页:31-36
部门归属: LMB
资助者: This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202), the Ministry of Science and Technology of China (2012AA092104, 2010CB833805) and the National Science Foundation of China (41006089, 41106143, 31125001). CZ is a scholar of the '100 Talents Project' of the Chinese Academy of Sciences (08SL111002). This study was funded by the Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903). We are grateful to analytical facilities in the South China Sea Institute of Oceanology.
摘要: The strain SCSIO 03039 was isolated from a sediment sample in the Indian Ocean and was characterized as a Nocardiopsis alba species on the basis of its 16S rRNA gene sequence. Seven diketopiperazines (DKPs), including two new DKPs nocazines D (2a) and E (2b), and five known DKPs (1, 3-6), were isolated from N. alba SCSIO 03039, along with two known compounds 2-methoxy-1,4-naphthoquinone (7) and 1-hydroxy-4-methoxy-2-naphthoic acid (8). Their structures were elucidated by mass and NMR spectroscopic analyses. The structure of methoxyneihumicin (1), previously proposed in a conference poster lacking publicly available experimental data, was validated for the first time by detailed NMR analyses and X-ray diffraction study. The two enantiomers nocazines D (2a) and E (2b) were isolated as a mixture. Compounds 3 and 4 were only known as synthetic compounds before. Methoxyneihumicin (1) exhibited in vitro cytotoxicities against MCF-7 and SF-268 with IC50 values of 4.6 and 12.7 mu M, respectively, better than those of 6 (22.0 and 20.6 mu M). The other compounds showed less pronounced cytotoxities against three tested human cancer cell lines and no compounds displayed antibacterial activities toward four indicator strains. The Journal of Antibiotics (2013) 66, 31-36; doi: 10.1038/ja.2012.88; published online 24 October 2012
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000314165300005
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11083
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Zhang, Qingbo; Li, Sumei; Tian, Xinpeng; Zhang, Haibo; Zhang, Guangtao; Zhu, Yiguang; Zhang, Si; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol,RNAM Ctr Marine Microbio, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Qingbo] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R China.New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039,JOURNAL OF ANTIBIOTICS,2013,66(1):31-36
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