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Shewanella oneidensis基因组上两对II型毒素-抗毒素系统的功能研究; Identification and Characterization of Two Type II Toxin-Antitoxin Pairs in Shewanella oneidensis
Thesis Advisor王晓雪
Degree Discipline海洋生物学
Keyword毒素-抗毒素系统 Mnt-hepn Shewanella Oneidensis 核酸内切酶 解旋酶抑制剂
Abstract毒素-抗毒素系统广泛分布在细菌与古菌基因组上,参与微生物的生长代谢调控。随着近些年对II型毒素-抗毒素系统广泛深入的研究,发现基因组上编码的II型毒素可作为RNase,切割胞内特定的RNA分子来调节胞内代谢速率。Shewanella oneidensis MR-1分离自Lake Oneida,是首株完成全基因测序的希瓦氏菌,由于其具有金属氧化还原能力而得到广泛的关注与研究。S. oneidensis 生存环境复杂多变,分析其基因组发现存在多对可能的毒素-抗毒素系统。本研究选取其中的两对II型毒素-抗毒素系统SO_3166/SO_3165和SO_1444/SO_1445作为研究对象。目前取得了以下研究成果: SO_3166/SO_3165 位于S. oneidensis基因组上, SO_3166属于HEPN超家族,SO_3165属于MNT超家族。生物信息学分析发现,HEPN-MNT成对存在时...
Other AbstractToxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Prokaryotic genomes contain toxin-antitoxin loci that induce cell dormancy in response to various stresses. Type II TA system is the most well-studied due to its abundance in bacterial genomes. Type II toxins originated from bacterial genome mainly function as RNase, which can increase the fitness through reducing cell metabolism. Shewanella oneidensis MR-1 was isolated from Lake Oneida, it is the first Shewanella spp. whose genome has been sequenced and thus serves as the model organism to study the functional repertoire of the Shewanella genus. However, related studies of TA systems in the ecologically and bioelectrochemically important strain Shewanella oneidensis are limited. Here, we identified and characterized two p...
Document Type学位论文
Recommended Citation
GB/T 7714
姚建云. Shewanella oneidensis基因组上两对II型毒素-抗毒素系统的功能研究, Identification and Characterization of Two Type II Toxin-Antitoxin Pairs in Shewanella oneidensis[D],2015.
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