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1,4-苯并噻嗪并二酮哌嗪衍生物的重排反应研究; Study of The Rearrangement of Benzo[b]pyrazino[1,2-d][1,4]thiazine-1,4-diones
Thesis Advisor刘永宏
Degree Discipline海洋化学
Keyword 重排反应 1 4-苯并噻嗪 二酮哌嗪 苯并噻唑
Other AbstractThe sulfur atom is not only electrophilic, but also nucleophilic. To date, nucleophilic was mostly used in organic synthesis, such as nucleophilic substitution reaction, Michael addition reaction, rearrangement reaction, the reaction of Sulfur ylides. In this paper, on the basis of sulfur-containing 2,5-diketopiperazines from natural marine products which exerts excellent biological activities, we synthesize a series of benzo[b]pyrazino[1,2-d][1,4]thiazine-1,4-diones according to the strategy of splice of pharmacophores of 1,4-benzothiazine and 2,5-diketopiperazine. Meanwhile, in vitro evaluation of these synthesized compounds, like anti-tumor, anti-bacterial, anti-influenza virus activities, showed that none of these compounds exerts significant bioactivity. However, we found that the novel benzo[4,5]thiazolo[3,2-a]pyrazine-1,4-diones derivatives could be generated by rearrangement reaction of sulfur atoms in the synthesis process of benzo[b]pyrazino[1,2-d] [1,4]thiazine-1,4-diones
Document Type学位论文
Recommended Citation
GB/T 7714
汤勇. 1,4-苯并噻嗪并二酮哌嗪衍生物的重排反应研究, Study of The Rearrangement of Benzo[b]pyrazino[1,2-d][1,4]thiazine-1,4-diones[D],2016.
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