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Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.
Wang, Jun-Feng1; He, Wei-Jun1; Zhang, Xiao-Xiao1; Zhao, Bi-Qing1; Liu, Yong-Hong1; Zhou, Xiao-Jiang1;
AbstractA new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11 (13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis, and single crystal X-ray diffraction analysis. Compound 1 possessed a dimeric sesquiterpene core featured with a cyclopentane ring connecting two sesquiterpene lactone units rarely discovered in nature. Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 mu M, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 mu M, respectively). (C) 2015 Elsevier Ltd. All rights reserved.
KeywordDimeric Sesquiterpene Carpesium Abrotanoides L. Cytotoxic Activity Antiviral Activity Antimycobacterial Activity
Subject AreaPharmacology & Pharmacy ; Chemistry
Document Type期刊论文
Affiliation1.[Wang, Jun-Feng
2.He, Wei-Jun
3.Zhang, Xiao-Xiao
4.Zhao, Bi-Qing
5.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
6.[Wang, Jun-Feng
7.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jun-Feng,He, Wei-Jun,Zhang, Xiao-Xiao,et al. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(19):4082-4084.
APA Wang, Jun-Feng.,He, Wei-Jun.,Zhang, Xiao-Xiao.,Zhao, Bi-Qing.,Liu, Yong-Hong.,...&, a new dimeric sesquiterpene from Carpesium abrotanoides L..BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(19),4082-4084.
MLA Wang, Jun-Feng,et al."Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.19(2015):4082-4084.
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