Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.
Wang, Jun-Feng1; He, Wei-Jun1; Zhang, Xiao-Xiao1; Zhao, Bi-Qing1; Liu, Yong-Hong1; Zhou, Xiao-Jiang1; gale9888@163.com
2015
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号25期号:19页码:4082-4084
摘要A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11 (13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis, and single crystal X-ray diffraction analysis. Compound 1 possessed a dimeric sesquiterpene core featured with a cyclopentane ring connecting two sesquiterpene lactone units rarely discovered in nature. Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 mu M, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 mu M, respectively). (C) 2015 Elsevier Ltd. All rights reserved.
部门归属LMB
关键词Dimeric Sesquiterpene Carpesium Abrotanoides L. Cytotoxic Activity Antiviral Activity Antimycobacterial Activity
学科领域Pharmacology & Pharmacy ; Chemistry
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14766
专题中科院海洋生物资源可持续利用重点实验室
通讯作者gale9888@163.com
作者单位1.[Wang, Jun-Feng
2.He, Wei-Jun
3.Zhang, Xiao-Xiao
4.Zhao, Bi-Qing
5.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
6.[Wang, Jun-Feng
7.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China
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Wang, Jun-Feng,He, Wei-Jun,Zhang, Xiao-Xiao,et al. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(19):4082-4084.
APA Wang, Jun-Feng.,He, Wei-Jun.,Zhang, Xiao-Xiao.,Zhao, Bi-Qing.,Liu, Yong-Hong.,...&gale9888@163.com.(2015).Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L..BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(19),4082-4084.
MLA Wang, Jun-Feng,et al."Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.19(2015):4082-4084.
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