Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds
Zhu, Yiguang1; Zhang, Wenjun1; Chen, Yaolong1; Yuan, Chengshan1; Zhang, Haibo1; Zhang, Guangtao1; Ma, Liang1; Zhang, Qingbo1; Tian, Xinpeng1; Zhang, Si1; Zhang, Changsheng1; czhang2006@gmail.com
2015
发表期刊CHEMBIOCHEM
卷号16期号:14页码:2086-2093
摘要Heronamides belong to a growing family of beta-amino acid polyketide macrolactams (beta PMs) with an unsaturated side chain. The biosynthetic gene cluster for heronamide F was identified from the deep-sea-derived Streptomyces sp. SCSIO 03032. The involvement of the gene cluster in heronamide biosynthesis was confirmed by the functional characterization of the P450 enzyme HerO as an 8-hydroxylase for tailoring heronamide biosynthesis. The presence of migrated double bonds in the conjugated diene-containing side chain of heronamides was confirmed by feeding experiments with labeled small carboxylic acid molecules. This study is the first demonstration of migrated double bonds in beta PMs with an unsaturated side chain.
部门归属LMB
关键词Biosynthesis Heronamides Hydroxylation Migrated Double Bonds Polyketides
学科领域Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14769
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
作者单位1.[Zhu, Yiguang
2.Zhang, Wenjun
3.Chen, Yaolong
4.Yuan, Chengshan
5.Zhang, Haibo
6.Zhang, Guangtao
7.Ma, Liang
8.Zhang, Qingbo
9.Tian, Xinpeng
10.Zhang, Si
11.Zhang, Changsheng] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Key Lab Trop Marine Bioresources & Ecol,Guangdong, Guangzhou 510301, Guangdong, Peoples R China
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Zhu, Yiguang,Zhang, Wenjun,Chen, Yaolong,et al. Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds[J]. CHEMBIOCHEM,2015,16(14):2086-2093.
APA Zhu, Yiguang.,Zhang, Wenjun.,Chen, Yaolong.,Yuan, Chengshan.,Zhang, Haibo.,...&czhang2006@gmail.com.(2015).Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds.CHEMBIOCHEM,16(14),2086-2093.
MLA Zhu, Yiguang,et al."Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds".CHEMBIOCHEM 16.14(2015):2086-2093.
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