Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation
Wang, Jun-Feng1; Qin, Xiaochu1; Xu, Fu-Quan1; Zhang, Tianyu1; Liao, Shengrong1; Lin, Xiuping1; Yang, Bin1; Liu, Juan1; Wang, Lishu1; Tu, Zhengchao1; Liu, Yonghong1; tu_zhengchao@gibh.ac.cn; yonghongliu@scsio.ac.cn
2015
发表期刊NATURAL PRODUCT RESEARCH
卷号29期号:18页码:1761-1765
摘要Fifteen compounds, including two tetramic acid derivatives, penicillenol A(1) (1) and penicillenol A(2) (2), six polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A-F (3-8), together with six phenolic bisabolane sesquiterpenoids (9-14) and diorcinol (15), were isolated from the fermentation broth of the marine-derived fungus ZSDS1-F11 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by using extensive NMR spectroscopic and mass spectrometric analyses. Compounds 3-5, 7 and 8 showed potent COX-1 inhibitory activity with IC50 values of 5.3, 16.2, 30.2, 41.0 and 56.8M, respectively. Meanwhile, compounds 3-8 showed potent COX-2 inhibitory activity with IC50 values of 3.1, 5.6, 3.0, 5.1, 3.2 and 3.7M, respectively. In addition, compound 1 exhibited antituberculosis activity with 96.1% inhibition at concentration of 10M.
部门归属LMB
关键词Marine Fungus Phakellia Fusca Thiele Tetramic Acid Polyphenol Anti-inflammatory Activity Antituberculosis Activity
学科领域Chemistry ; Pharmacology & Pharmacy
URL查看原文
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14771
专题中科院海洋生物资源可持续利用重点实验室
通讯作者tu_zhengchao@gibh.ac.cn; yonghongliu@scsio.ac.cn
作者单位1.[Wang, Jun-Feng
2.Liao, Shengrong
3.Lin, Xiuping
4.Yang, Bin
5.Liu, Juan
6.Liu, Yonghong] Chinese Acad Sci, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China
7.[Qin, Xiaochu
8.Zhang, Tianyu
9.Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
10.[Xu, Fu-Quan] Huaihai Inst Technol, Jiangsu Key Lab Marine Biotechnol, Lianyungang 222005, Peoples R China
11.[Wang, Lishu] Jilin Prov Acad Chinese Med Sci, Changchun 130021, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jun-Feng,Qin, Xiaochu,Xu, Fu-Quan,et al. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation[J]. NATURAL PRODUCT RESEARCH,2015,29(18):1761-1765.
APA Wang, Jun-Feng.,Qin, Xiaochu.,Xu, Fu-Quan.,Zhang, Tianyu.,Liao, Shengrong.,...&yonghongliu@scsio.ac.cn.(2015).Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation.NATURAL PRODUCT RESEARCH,29(18),1761-1765.
MLA Wang, Jun-Feng,et al."Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation".NATURAL PRODUCT RESEARCH 29.18(2015):1761-1765.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。