Synthesis of a Class of Chiral-Bridged Phosphoramidite Ligands and Their Applications in the First Iridium-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatins
Zhuang, Yue1; He, Yuwei1; Zhou, Zihong1; Xia, Wang1; Cheng, Chuyu1; Wang, Meng1; Chen, Bin1; Zhou, Zhongyuan1; Pang, Jiyan1; Qiu, Liqin1; qiuliqin@mail.sysu.edu.cn
2015
发表期刊JOURNAL OF ORGANIC CHEMISTRY
卷号80期号:14页码:6968-6975
摘要A series of novel chiral phosphoramidite ligands based on chiral-bridged biphenyl backbones have been prepared conveniently and characterized. The ligands complexed with [IrCodCl](2) provided the first iridium catalyst system for the asymmetric addition of arylboronic acids to N-protected isatins with high efficiency. When performed in THF/H2O at 80 degrees C with 2 equiv of the arylboronic acids, the transformations acquired good to excellent results (up to 98% yield and 95% ee).
部门归属LMB
学科领域Chemistry
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14800
专题中科院海洋生物资源可持续利用重点实验室
通讯作者qiuliqin@mail.sysu.edu.cn
作者单位1.[Zhuang, Yue
2.He, Yuwei
3.Zhou, Zihong
4.Xia, Wang
5.Cheng, Chuyu
6.Wang, Meng
7.Chen, Bin
8.Pang, Jiyan
9.Qiu, Liqin] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Key Lab Low Carbon Chem & Energy Conservat Guangd, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
10.[Qiu, Liqin] Sun Yat Sen Univ, Huizhou Res Inst, Dayawan 516000, Huizhou, Peoples R China
11.[Zhou, Zhongyuan] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China
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Zhuang, Yue,He, Yuwei,Zhou, Zihong,et al. Synthesis of a Class of Chiral-Bridged Phosphoramidite Ligands and Their Applications in the First Iridium-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatins[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(14):6968-6975.
APA Zhuang, Yue.,He, Yuwei.,Zhou, Zihong.,Xia, Wang.,Cheng, Chuyu.,...&qiuliqin@mail.sysu.edu.cn.(2015).Synthesis of a Class of Chiral-Bridged Phosphoramidite Ligands and Their Applications in the First Iridium-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatins.JOURNAL OF ORGANIC CHEMISTRY,80(14),6968-6975.
MLA Zhuang, Yue,et al."Synthesis of a Class of Chiral-Bridged Phosphoramidite Ligands and Their Applications in the First Iridium-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatins".JOURNAL OF ORGANIC CHEMISTRY 80.14(2015):6968-6975.
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