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Antiviral Limonoids Including Khayanolides from the Trang Mangrove Plant Xylocarpus moluccensis
Li, Wanshan1; Jiang, Zhongping1; Shen, Li1; Pedpradab, Patchara1; Bruhn, Torsten1; Wu, Jun1; Bringmann, Gerhard1;;;
AbstractEight new khayanolides, named thaixylomolins G-N (1-8), two new phragmalins (9 and 10), and two new mexicanolides (11 and 12) were obtained from the seeds of the Trang mangrove plant Xylocarpus moluccensis. The absolute configurations of these limonoids, except for the stereocenter at C-6 of 11 and 12, were assigned by experimental and TDDFT calculated electronic circular dichroism spectra. The khayanolides may be classified into two subclasses, one of which has a C-2 carbonyl and a 3 beta-acetoxy group, whereas the other possesses a 2 beta-acetoxy and a C-3 carbonyl function. Khayanolides, rearranged phragmalin-type limonoids, are reported for the first time from plants of the mangrove genus Xylocarpus. The structure of moluccensin J, a known 30-ketophragmalin containing a Delta(8(14)) double bond, was revised to be a khayanolide, named thaixylomolin K. The antiviral activities of the isolates against pandemic influenza A virus (subtype H1N1) were tested by the assay of cytopathic effect inhibition. Three khayanolides, viz., thaixylomolins I, K, and M, exhibited moderate anti-H1N1 activities. The most potent one, thaixylomolin I (IC50 = 77.1 +/- 8.7 mu M), showed stronger inhibitory activity than that of the positive control, ribavirin (IC50 = 185.9 +/- 16.8 mu M).
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Document Type期刊论文
Affiliation1.[Li, Wanshan] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
2.[Jiang, Zhongping
3.Shen, Li
4.Wu, Jun] Jinan Univ, Coll Pharm, Marine Drugs Res Ctr, Guangzhou 510632, Guangdong, Peoples R China
5.[Pedpradab, Patchara] Rajamangala Univ Technol Srivijaya, Fac Sci & Fishery Technol, Dept Marine Sci, Sikao Dist 92150, Trang Province, Thailand
6.[Bruhn, Torsten
7.Bringmann, Gerhard] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
8.[Li, Wanshan] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Wanshan,Jiang, Zhongping,Shen, Li,et al. Antiviral Limonoids Including Khayanolides from the Trang Mangrove Plant Xylocarpus moluccensis[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(7):1570-1578.
APA Li, Wanshan.,Jiang, Zhongping.,Shen, Li.,Pedpradab, Patchara.,Bruhn, Torsten.,...& Limonoids Including Khayanolides from the Trang Mangrove Plant Xylocarpus moluccensis.JOURNAL OF NATURAL PRODUCTS,78(7),1570-1578.
MLA Li, Wanshan,et al."Antiviral Limonoids Including Khayanolides from the Trang Mangrove Plant Xylocarpus moluccensis".JOURNAL OF NATURAL PRODUCTS 78.7(2015):1570-1578.
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