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The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)
Liang, Yan-Qiu1; Huang, Guo-Yong1; Ying, Guang-Guo1; Liu, Shuang-Shuang1; Jiang, Yu-Xia1; Liu, Shan1; Peng, Feng-Jiao1; guangguo.ying@gmail.com
2015
Source PublicationCHEMOSPHERE
Volume128Pages:199-206
AbstractProgesterone (P4) has been reported in surface water, and it may have adverse effects on aquatic organisms. This study provided the transcriptional effects of P4 during the early development of zebrafish. Zebrafish embryos were exposed for 144 h post fertilization (hpf) to 0, 6, 45 and 90 ng L-1 P4, and transcriptional expression profiles of the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes were assessed every day. For the receptor signaling pathways, P4 significantly induced the transcript of Pgr gene above 45 ng L-1 at 72 and 144 hpf, but inhibited its transcript above 6 ng L-1 at 96 and 120 hpf. A significant up-regulation of Vtgl mRNA was observed at 6 ng L-1 P4 or higher at 24, 96 and 144 hpf. For the steroidogenic pathways, the transcriptional expression of Cyp11a1 and Hsd17b3 mRNAs was mediated by 6 ng L-1 P4 or higher according to different exposure time points. In addition, P4 resulted in a significant induction of Cyp19a1a and Cyp11b mRNA expression while it caused a significant inhibition of Hs11b2 mRNA expression above 6 ng L-1. For the other target genes related to hypothalamic and pituitary hormones, P4 mainly modulated the transcripts of Gnrh2, Fshb and Lhb genes at 6 ng L-1 or higher. The overall results from the present study indicate that P4 at environmentally relevant concentrations could cause the potential effects on zebrafish reproductive and adrenal endocrine systems by interfering with the HPG and HPA axes. (C) 2015 Elsevier Ltd. All rights reserved.
DepartmentLMB
KeywordHypothalamic-pituitary-gonadal Axis Hypothalamic-pituitary-adrenal Axis Progesterone Zebrafish
Subject AreaEnvironmental Sciences & Ecology
URL查看原文
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/14830
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorguangguo.ying@gmail.com
Affiliation1.[Liang, Yan-Qiu
2.Huang, Guo-Yong
3.Ying, Guang-Guo
4.Liu, Shuang-Shuang
5.Jiang, Yu-Xia
6.Liu, Shan
7.Peng, Feng-Jiao] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China
8.[Liu, Shan] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,et al. The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)[J]. CHEMOSPHERE,2015,128:199-206.
APA Liang, Yan-Qiu.,Huang, Guo-Yong.,Ying, Guang-Guo.,Liu, Shuang-Shuang.,Jiang, Yu-Xia.,...&guangguo.ying@gmail.com.(2015).The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio).CHEMOSPHERE,128,199-206.
MLA Liang, Yan-Qiu,et al."The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)".CHEMOSPHERE 128(2015):199-206.
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