The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)
Liang, Yan-Qiu1; Huang, Guo-Yong1; Ying, Guang-Guo1; Liu, Shuang-Shuang1; Jiang, Yu-Xia1; Liu, Shan1; Peng, Feng-Jiao1; guangguo.ying@gmail.com
2015
发表期刊CHEMOSPHERE
卷号128页码:199-206
摘要Progesterone (P4) has been reported in surface water, and it may have adverse effects on aquatic organisms. This study provided the transcriptional effects of P4 during the early development of zebrafish. Zebrafish embryos were exposed for 144 h post fertilization (hpf) to 0, 6, 45 and 90 ng L-1 P4, and transcriptional expression profiles of the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes were assessed every day. For the receptor signaling pathways, P4 significantly induced the transcript of Pgr gene above 45 ng L-1 at 72 and 144 hpf, but inhibited its transcript above 6 ng L-1 at 96 and 120 hpf. A significant up-regulation of Vtgl mRNA was observed at 6 ng L-1 P4 or higher at 24, 96 and 144 hpf. For the steroidogenic pathways, the transcriptional expression of Cyp11a1 and Hsd17b3 mRNAs was mediated by 6 ng L-1 P4 or higher according to different exposure time points. In addition, P4 resulted in a significant induction of Cyp19a1a and Cyp11b mRNA expression while it caused a significant inhibition of Hs11b2 mRNA expression above 6 ng L-1. For the other target genes related to hypothalamic and pituitary hormones, P4 mainly modulated the transcripts of Gnrh2, Fshb and Lhb genes at 6 ng L-1 or higher. The overall results from the present study indicate that P4 at environmentally relevant concentrations could cause the potential effects on zebrafish reproductive and adrenal endocrine systems by interfering with the HPG and HPA axes. (C) 2015 Elsevier Ltd. All rights reserved.
部门归属LMB
关键词Hypothalamic-pituitary-gonadal Axis Hypothalamic-pituitary-adrenal Axis Progesterone Zebrafish
学科领域Environmental Sciences & Ecology
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14830
专题中科院海洋生物资源可持续利用重点实验室
通讯作者guangguo.ying@gmail.com
作者单位1.[Liang, Yan-Qiu
2.Huang, Guo-Yong
3.Ying, Guang-Guo
4.Liu, Shuang-Shuang
5.Jiang, Yu-Xia
6.Liu, Shan
7.Peng, Feng-Jiao] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China
8.[Liu, Shan] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
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Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,et al. The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)[J]. CHEMOSPHERE,2015,128:199-206.
APA Liang, Yan-Qiu.,Huang, Guo-Yong.,Ying, Guang-Guo.,Liu, Shuang-Shuang.,Jiang, Yu-Xia.,...&guangguo.ying@gmail.com.(2015).The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio).CHEMOSPHERE,128,199-206.
MLA Liang, Yan-Qiu,et al."The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)".CHEMOSPHERE 128(2015):199-206.
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