Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium
Wang, Jun-Feng1; Yang, Sheng-Hui1; Liu, Yan-Qun1; Li, Din-Xiang1; He, Wei-Jun1; Zhang, Xiao-Xiao1; Liu, Yong-Hong1; Zhou, Xiao-Jiang1; yonghongliu@scsio.ac.cn; gale9888@163.com
2015
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号25期号:9页码:1986-1989
摘要Five new phorbol esters, (four phorbol diesters, 1-4, and one 4-deoxy-4 alpha-phorbol diester, 5), as well as four known phorbol esters analogues (6-9) were isolated and identified from the branches and leaves of Croton tiglium. Their structures were elucidated mainly by extensive NMR spectroscopic, and mass spectrometric analysis. Among them, compound (1) was the first example of a naturally occurring phorbol ester with the 20-aldehyde group. Compounds 2-5, and 7-9 showed potent cytotoxicity against the K562, A549, DU145, H1975, MCF-7, U937, SGC-7901, HL60, Hela, and MOLT-4 cell lines, with IC50 values ranging from 1.0 to 43 mu M, while none of the compounds exhibited cytotoxic effects on normal human cell lines 293T and LX-2, respectively. In addition, compound 3 exhibited moderate COX-1 and COX-2 inhibition, with IC50 values of 0.14 and 8.5 mu M, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
部门归属LMB
关键词Croton Tiglium Phorbol Esters Cytotoxicity Anti-inflammatory Activity
学科领域Pharmacology & Pharmacy ; Chemistry
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14837
专题中科院海洋生物资源可持续利用重点实验室
通讯作者yonghongliu@scsio.ac.cn; gale9888@163.com
作者单位1.[Wang, Jun-Feng
2.Yang, Sheng-Hui
3.Liu, Yan-Qun
4.He, Wei-Jun
5.Zhang, Xiao-Xiao
6.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
7.[Wang, Jun-Feng
8.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
9.[Li, Din-Xiang] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
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Wang, Jun-Feng,Yang, Sheng-Hui,Liu, Yan-Qun,et al. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(9):1986-1989.
APA Wang, Jun-Feng.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Li, Din-Xiang.,He, Wei-Jun.,...&gale9888@163.com.(2015).Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(9),1986-1989.
MLA Wang, Jun-Feng,et al."Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.9(2015):1986-1989.
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