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Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium
Wang, Jun-Feng1; Yang, Sheng-Hui1; Liu, Yan-Qun1; Li, Din-Xiang1; He, Wei-Jun1; Zhang, Xiao-Xiao1; Liu, Yong-Hong1; Zhou, Xiao-Jiang1; yonghongliu@scsio.ac.cn; gale9888@163.com
2015
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume25Issue:9Pages:1986-1989
AbstractFive new phorbol esters, (four phorbol diesters, 1-4, and one 4-deoxy-4 alpha-phorbol diester, 5), as well as four known phorbol esters analogues (6-9) were isolated and identified from the branches and leaves of Croton tiglium. Their structures were elucidated mainly by extensive NMR spectroscopic, and mass spectrometric analysis. Among them, compound (1) was the first example of a naturally occurring phorbol ester with the 20-aldehyde group. Compounds 2-5, and 7-9 showed potent cytotoxicity against the K562, A549, DU145, H1975, MCF-7, U937, SGC-7901, HL60, Hela, and MOLT-4 cell lines, with IC50 values ranging from 1.0 to 43 mu M, while none of the compounds exhibited cytotoxic effects on normal human cell lines 293T and LX-2, respectively. In addition, compound 3 exhibited moderate COX-1 and COX-2 inhibition, with IC50 values of 0.14 and 8.5 mu M, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
DepartmentLMB
KeywordCroton Tiglium Phorbol Esters Cytotoxicity Anti-inflammatory Activity
Subject AreaPharmacology & Pharmacy ; Chemistry
URL查看原文
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/14837
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoryonghongliu@scsio.ac.cn; gale9888@163.com
Affiliation1.[Wang, Jun-Feng
2.Yang, Sheng-Hui
3.Liu, Yan-Qun
4.He, Wei-Jun
5.Zhang, Xiao-Xiao
6.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
7.[Wang, Jun-Feng
8.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
9.[Li, Din-Xiang] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jun-Feng,Yang, Sheng-Hui,Liu, Yan-Qun,et al. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(9):1986-1989.
APA Wang, Jun-Feng.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Li, Din-Xiang.,He, Wei-Jun.,...&gale9888@163.com.(2015).Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(9),1986-1989.
MLA Wang, Jun-Feng,et al."Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.9(2015):1986-1989.
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