Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host
Li, Qinglian1; Song, Yongxiang1; Qin, Xiangjing1; Zhang, Xing1; Sun, Aijun1; Ju, Jianhua1; jju@scsio.ac.cn
2015
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号78期号:4页码:944-948
摘要The desotamides (DSAs) are potent antibacterial cyclohexapeptides produced by Streptomyces scopuliridis SCSIO ZJ46. We have identified the 39-kb dsa biosynthetic gene cluster by whole-genome scanning. Composed of 17 open reading frames, the cluster codes for four nonribosomal peptide synthetases and associated resistance, transport, regulatory, and precursor biosynthesis proteins. Heterologous expression of the dsa gene cluster in S. coelicolor M1152 afforded desotamides A and B and the new desotamide G. Cluster identification and its demonstrated amenability to heterologous expression provide the foundation for future mechanistic studies as well as the generation of new and potentially clinically significant DSA analogues.
部门归属LMB
学科领域Plant Sciences ; Pharmacology & Pharmacy
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14841
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn
作者单位1.[Li, Qinglian
2.Song, Yongxiang
3.Qin, Xiangjing
4.Zhang, Xing
5.Sun, Aijun
6.Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China
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Li, Qinglian,Song, Yongxiang,Qin, Xiangjing,et al. Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(4):944-948.
APA Li, Qinglian.,Song, Yongxiang.,Qin, Xiangjing.,Zhang, Xing.,Sun, Aijun.,...&jju@scsio.ac.cn.(2015).Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host.JOURNAL OF NATURAL PRODUCTS,78(4),944-948.
MLA Li, Qinglian,et al."Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host".JOURNAL OF NATURAL PRODUCTS 78.4(2015):944-948.
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