Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594
Song, Yongxiang1; Liu, Guangfu1; Li, Jie1; Huang, Hongbo1; Zhang, Xing1; Zhang, Hua1; Ju, Jianhua1; songx@scsio.ac.cn; 454143108@qq.com; lijietaren@yeah.net; huanghb@scsio.ac.cn; beishidazhangxing@163.com; zhanghuahh11@126.com; jju@scsio.ac.cn
2015
发表期刊MARINE DRUGS
卷号13期号:3页码:1304-1316
摘要Two new C-glycoside angucyclines, marangucycline A (1) and marangucycline B (2), along with three known compounds, dehydroxyaquayamycin (3), undecylprodigiosin (4) and metacycloprodigiosin (5), have been identified as products of the deep-sea sediment strain Streptomyces sp. SCSIO 11594. New structures were elucidated on the basis of HRESIMS, 1D and 2D NMR analyses and comparisons to previously reported datasets. Compounds 2 and 4 displayed in vitro cytotoxicity against four cancer cell lines A594, CNE2, HepG2, MCF-7 superior to those obtained with cisplatin, the positive control. Notably, compound 2 bearing a keto-sugar displayed significant cytotoxicity against cancer cell lines with IC50 values ranging from 0.24 to 0.56 mu M; An IC50 value of 3.67 mu M was found when using non-cancerous hepatic cell line HL7702, demonstrating the cancer cell selectivity of 2. Compounds 1-3 were proved to have weak antibacterial activities against Enterococcus faecalis ATCC29212 with an MIC value of 64.0 mu g/mL. Moreover, 3 displayed selective antibacterial activity against methicillin-resistant Staphylococcus epidermidis shhs-E1 with an MIC value of 16.0 mu g/mL.
部门归属LMB
学科领域Pharmacology & Pharmacy
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14855
专题中科院海洋生物资源可持续利用重点实验室
通讯作者songx@scsio.ac.cn; 454143108@qq.com; lijietaren@yeah.net; huanghb@scsio.ac.cn; beishidazhangxing@163.com; zhanghuahh11@126.com; jju@scsio.ac.cn
作者单位1.[Song, Yongxiang
2.Li, Jie
3.Huang, Hongbo
4.Zhang, Xing
5.Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
6.[Liu, Guangfu
7.Zhang, Hua] Guangdong Med Coll, Guangdong Prov Key Lab Med Mol Diagnost, Inst Clin Lab Med, Dept Clin Biochem, Dongguan 523808, Peoples R China
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Song, Yongxiang,Liu, Guangfu,Li, Jie,et al. Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594[J]. MARINE DRUGS,2015,13(3):1304-1316.
APA Song, Yongxiang.,Liu, Guangfu.,Li, Jie.,Huang, Hongbo.,Zhang, Xing.,...&jju@scsio.ac.cn.(2015).Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594.MARINE DRUGS,13(3),1304-1316.
MLA Song, Yongxiang,et al."Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594".MARINE DRUGS 13.3(2015):1304-1316.
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