Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis
Gui, Chun1; Li, Qinglian1; Mo, Xuhua1; Qin, Xiangjing1; Ma, Junying1; Ju, Jianhua1; jju@scsio.ac.cn
2015
发表期刊ORGANIC LETTERS
卷号17期号:3页码:628-631
摘要Bioinformatic analyses indicate that TrdC, SlgL, LipX(2), KirHI, and FacHI belong to a group of highly homologous proteins involved in biosynthesis of actinomycete-derived tirandamycin B, streptolydigin, alpha-lipomycin, kirromycin, and factumycin, respectively. However, assignment of their biosynthetic roles has remained elusive. Gene inactivation and complementation, in vitro biochemical assays with synthetic analogues, point mutations, and phylogenetic tree analyses reveal that these proteins represent a new family of Dieckmann cyclases that drive tetramic acid and pyridone scaffold biosynthesis.
部门归属LMB
学科领域Chemistry
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14863
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn
作者单位1.[Gui, Chun
2.Li, Qinglian
3.Mo, Xuhua
4.Qin, Xiangjing
5.Ma, Junying
6.Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
7.[Gui, Chun] Univ Chinese Acad Sci, Beijing 110039, Peoples R China
8.[Mo, Xuhua] Qingdao Agr Univ, Sch Life Sci, Shandong Key Lab Appl Mycol, Qingdao 266109, Peoples R China
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Gui, Chun,Li, Qinglian,Mo, Xuhua,et al. Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis[J]. ORGANIC LETTERS,2015,17(3):628-631.
APA Gui, Chun.,Li, Qinglian.,Mo, Xuhua.,Qin, Xiangjing.,Ma, Junying.,...&jju@scsio.ac.cn.(2015).Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis.ORGANIC LETTERS,17(3),628-631.
MLA Gui, Chun,et al."Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis".ORGANIC LETTERS 17.3(2015):628-631.
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