Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp HH1 ZSDS1F1-2
Qin, Chun1; Lin, Xiuping1; Lu, Xin1; Wan, Junting1; Zhou, Xuefeng1; Liao, Shengrong1; Tu, Zhengchao1; Xu, Shihai1; Liu, Yonghong1; tu_zhengchao@gibh.ac.cn; txush@jnu.edu.cn; yonghongliu@scsio.ac.cn
2015
发表期刊JOURNAL OF ANTIBIOTICS
卷号68期号:2页码:121-125
摘要A new (2) and four known (1, 8-10) sesquiterpenoids, two new (3 and 4) and eight known (5-7, 11-15) xanthone derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. HH1 ZDDS1F1-2. The structure of the compounds 1-15 was determined mainly by analysis of the one-dimensional and two-dimensional NMR spectroscopic data and by analogy with the data of those reported. Compound 1 was confirmed by X-ray crystallography. All the compounds were tested for their cytotoxic, antiinflammatory and antiviral (EV71) effects. Compounds 5, 7 and 11 showed significant cytotoxicity against selected human tumor cell lines. Compounds 3, 4 and 11 also displayed significant inhibitory activity against cycloooxygenase (COX-2). Compounds 4, 5 and 11 showed activities against intestinal virus EV71.
部门归属LMB
学科领域Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
URL查看原文
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14868
专题中科院海洋生物资源可持续利用重点实验室
通讯作者tu_zhengchao@gibh.ac.cn; txush@jnu.edu.cn; yonghongliu@scsio.ac.cn
作者单位1.[Qin, Chun
2.Lin, Xiuping
3.Zhou, Xuefeng
4.Liao, Shengrong
5.Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510530, Guangdong, Peoples R China
6.[Qin, Chun
7.Xu, Shihai] Jinan Univ, Dept Chem, Guangzhou, Guangdong, Peoples R China
8.[Lu, Xin
9.Wan, Junting
10.Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
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GB/T 7714
Qin, Chun,Lin, Xiuping,Lu, Xin,et al. Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp HH1 ZSDS1F1-2[J]. JOURNAL OF ANTIBIOTICS,2015,68(2):121-125.
APA Qin, Chun.,Lin, Xiuping.,Lu, Xin.,Wan, Junting.,Zhou, Xuefeng.,...&yonghongliu@scsio.ac.cn.(2015).Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp HH1 ZSDS1F1-2.JOURNAL OF ANTIBIOTICS,68(2),121-125.
MLA Qin, Chun,et al."Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp HH1 ZSDS1F1-2".JOURNAL OF ANTIBIOTICS 68.2(2015):121-125.
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