The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China
Chen, Baowei1; Liang, Ximei1; Nie, Xiangping1; Huang, Xiaoping1; Zou, Shichun1; Li, Xiangdong1; cexdli@polyu.edu.hk
2015
发表期刊JOURNAL OF HAZARDOUS MATERIALS
卷号282期号:SI页码:61-67
摘要Antibiotic resistance genes (ARGs), as a newly emerging contaminant, are unique because they are disseminated through horizontal gene transfer in the environment. In the present study, a class 1 integron gene (Int1) and various ARGs (sul1, sul2, sul3, qnrS, and ermB) were measured in water and sediment samples from the Pearl River (PR) to the Pearl River Estuary (PRE), where there is a distinct gradient in anthropogenic impact. The int1, sul1, and sul2 genes were detected in all samples, and their concentrations exhibited a clear trend of decline consistent with anthropogenic impact. Both the int1 and sul genes had dynamically migrated between water and sediments. The relative abundance of the Intl gene normalized to the 16S rRNA gene correlated significantly with the total concentrations of antibiotics in water and sediments. Good correlations were also observed between the abundance of Intl and each type of sul gene in the samples. However, the sul1 gene showed a much stronger relationship with intl in different seasons, probably due to the presence of sul1 in the conserved region of class 1 integron. Our results strongly support that integrons play an important role in the dissemination of ARGs in human-impacted aquatic environments. (C) 2014 Elsevier B.V. All rights reserved.
部门归属LMB
关键词Antibiotic Resistance Genes (Arc) Sulfonamide Resistance Genes (Sul1 And Sul2) Class 1 Intergron Pearl River Estuary (Pre) South China
学科领域Engineering ; Environmental Sciences & Ecology
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14879
专题中科院海洋生物资源可持续利用重点实验室
通讯作者cexdli@polyu.edu.hk
作者单位1.[Chen, Baowei
2.Li, Xiangdong] Hong Kong Polytech Univ, Dept Civil & Environm Engn, Kowloon, Hong Kong, Peoples R China
3.[Chen, Baowei
4.Zou, Shichun] Sun Yat Sen Univ, Sch Marine Sci, Guangzhou 510275, Guangdong, Peoples R China
5.[Liang, Ximei
6.Huang, Xiaoping] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
7.[Liang, Ximei] Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou 510380, Guangdong, Peoples R China
8.[Nie, Xiangping] Jinan Univ, Inst Hydrobiol, Dept Ecol, Guangzhou 510632, Guangdong, Peoples R China
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Chen, Baowei,Liang, Ximei,Nie, Xiangping,et al. The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China[J]. JOURNAL OF HAZARDOUS MATERIALS,2015,282(SI):61-67.
APA Chen, Baowei.,Liang, Ximei.,Nie, Xiangping.,Huang, Xiaoping.,Zou, Shichun.,...&cexdli@polyu.edu.hk.(2015).The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China.JOURNAL OF HAZARDOUS MATERIALS,282(SI),61-67.
MLA Chen, Baowei,et al."The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China".JOURNAL OF HAZARDOUS MATERIALS 282.SI(2015):61-67.
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