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Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
Li, Huixian1; Sun, Yu1; Zhang, Qingbo1; Zhu, Yiguang1; Li, Shu-Ming1; Li, Ang1; Zhang, Changsheng1; czhang2006@gmail.com
2015
Source PublicationORGANIC LETTERS
Volume17Issue:2Pages:306-309
AbstractIndolosesquiterpene xiamycin A features a pentacyclic core structure. The chemical synthesis of two key precursors, 3-farnesylindole and 3-(epoxyfarnesyl)-indole, allowed elucidation of the enzymatic cascades forming the pentacyclic ring system of xiamycin A by XiaO-catalyzed epoxidation and the membrane protein XiaH-catalyzed terpene cyclization. The substrate flexibility of XiaI, an indole oxygenase for assembly of the central ring, was also demonstrated.
DepartmentLMB
Subject AreaChemistry
URL查看原文
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/14882
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorczhang2006@gmail.com
Affiliation1.[Li, Huixian
2.Zhang, Qingbo
3.Zhu, Yiguang
4.Zhang, Changsheng] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
5.[Sun, Yu
6.Li, Ang] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
7.[Li, Shu-Ming] Univ Marburg, Inst Pharmazeut Biol & Biotechnol, D-35037 Marburg, Germany
Recommended Citation
GB/T 7714
Li, Huixian,Sun, Yu,Zhang, Qingbo,et al. Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations[J]. ORGANIC LETTERS,2015,17(2):306-309.
APA Li, Huixian.,Sun, Yu.,Zhang, Qingbo.,Zhu, Yiguang.,Li, Shu-Ming.,...&czhang2006@gmail.com.(2015).Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations.ORGANIC LETTERS,17(2),306-309.
MLA Li, Huixian,et al."Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations".ORGANIC LETTERS 17.2(2015):306-309.
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