Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae
Liang, Yan-Qiu1; Huang, Guo-Yong1; Ying, Guang-Guo1; Liu, Shuang-Shuang1; Jiang, Yu-Xia1; Liu, Shan1; guangguo.ying@gmail.com
2015
发表期刊COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷号167页码:101-107
摘要The aim of this study was to investigate the effects of progestins on the hypothalamic-pituitary-thyroid (HPT) axis in the early stage of zebrafish. Zebrafish embryos were exposed to progesterone (P4) or norgestrel (NGT) at 5, 50 and 100 ng L-1 for 144 h post fertilization (hpf), and the transcriptional levels of target genes along the hypothalamic-pituitary-thyroid axis were determined daily. The results showed that P4 had only minor effects on the mRNA expression of thyroglobulin (Tg), iodothyronine deiodinase type I (Dio1) and thyroid hormone receptor beta (Thrb) genes. Similarly, the effects of NGT on transcripts of thyrotropin-releasing hormone (Trh), Dio1, iodothyronine deiodinase type II (Dio2) and thyroid hormone receptor alpha (Thra) genes were generally low. In addition, NGT resulted in some alterations of Tg and Thrb transcripts at different time points. However, a strong induction of Nis mRNA by P4 and NGT was observed in zebrafish embryos-larvae. The overall results showed that besides Nis no effects on the hypothalamic-pituitary-thyroid (HPT) axis are observed following exposure to P4 and NGT, which imply that both P4 and NGT have potential effects on the thyroid endocrine system by inducing transcript of Nis gene during the early stage of zebrafish. (C) 2014 Elsevier Inc All rights reserved.
部门归属LMB
关键词Gene Transcription Hypothalamic-pituitary-thyroid Axis Norgestrel Progesterone
学科领域Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14893
专题中科院海洋生物资源可持续利用重点实验室
通讯作者guangguo.ying@gmail.com
作者单位1.[Liang, Yan-Qiu
2.Huang, Guo-Yong
3.Ying, Guang-Guo
4.Liu, Shuang-Shuang
5.Jiang, Yu-Xia
6.Liu, Shan] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China
7.[Liu, Shan] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine BioResources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
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Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,et al. Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2015,167:101-107.
APA Liang, Yan-Qiu.,Huang, Guo-Yong.,Ying, Guang-Guo.,Liu, Shuang-Shuang.,Jiang, Yu-Xia.,...&guangguo.ying@gmail.com.(2015).Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,167,101-107.
MLA Liang, Yan-Qiu,et al."Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 167(2015):101-107.
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