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Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis
Wang, Junfeng1; Wang, Zhen1; Ju, Zhiran1; Wan, Junting1; Liao, Shengrong1; Lin, Xiuping1; Zhang, Tianyu1; Zhou, Xuefeng1; Chen, Hao1; Tu, Zhengchao1; Liu, Yonghong1;
Source PublicationPLANTA MEDICA
AbstractFour new cytochalasins, arthriniumnins A-D (1-4), a new natural product, ketocytochalasin (5), as well as five known cytochalasin analogues (6-10) were isolated and identified from the fungus Arthrinium arundinis ZSDS1-F3 from the sponge Phakellia fusca. Their structures were elucidated by NMR spectroscopic and mass spectrometric analyses, as well as single crystal X-ray diffraction. Compounds 6 and 9 showed cytotoxicity against K562, A549, Huh-7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4 cell lines, with IC50 values ranging from 1.13 to 47.4 mu M.
KeywordArthrinium Arundinis Apiosporaceae Sponge Marine Fungus Cytochalasin Cytotoxic Activity
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Document Type期刊论文
Affiliation1.[Wang, Zhen
2.Wan, Junting
3.Zhang, Tianyu
4.Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
5.[Wang, Junfeng
6.Liao, Shengrong
7.Lin, Xiuping
8.Zhou, Xuefeng
9.Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510530, Guangdong, Peoples R China
10.[Chen, Hao] State Ocean Adm Republ China, Key Lab Marine Bioact Subst, Inst Oceanog 1, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Wang, Junfeng,Wang, Zhen,Ju, Zhiran,et al. Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis[J]. PLANTA MEDICA,2015,81(2):160-166.
APA Wang, Junfeng.,Wang, Zhen.,Ju, Zhiran.,Wan, Junting.,Liao, Shengrong.,...& Cytochalasins from Marine-Derived Fungus Arthrinium arundinis.PLANTA MEDICA,81(2),160-166.
MLA Wang, Junfeng,et al."Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis".PLANTA MEDICA 81.2(2015):160-166.
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