A TIME-COURSE TRANSCRIPTIONAL KINETICS OF THE HYPOTHALAMIC-PITUITARY-GONADAL AND HYPOTHALAMIC-PITUITARY-ADRENAL AXES IN ZEBRAFISH ELEUTHEROEMBRYOS AFTER EXPOSURE TO NORGESTREL
Liang, Yan-Qiu1; Huang, Guo-Yong1; Ying, Guang-Guo1; Liu, Shuang-Shuang1; Jiang, Yu-Xia1; Liu, Shan1; Peng, Feng-jiao1; guang-guo.ying@gig.ac.cn
2015
发表期刊ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷号34期号:1页码:112-119
摘要The objective of the present study was to investigate the effects of norgestrel on the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes in zebrafish eleutheroembryos. Zebrafish embryos were exposed to different concentrations of norgestrel (0ngL(-1), 5ngL(-1), 50ngL(-1), and 100ngL(-1)) for 144h post fertilization (hpf), and the transcriptional profiles of the HPG and HPA axes were examined every day. Norgestrel modulated the expression of Pgr and Vtg1 messenger (m)RNAs mainly at 96 hpf for all treatment groups. In addition, norgestrel strongly altered the expression of Cyp11a1 mRNA above 5ngL(-1) (significant upregulation from 48 hpf to 120 hpf and significant downregulation for 144 hpf). Norgestrel treatment could significantly induce expression of Cyp19a1a, Cyp11b, Gnrh2, Gnrh3, and Lhb mRNAs but inhibit transcripts of Hsd11b2 and Crh genes above 5ngL(-1) at different time points. The transcriptional expression levels of Esr1, Ar, Star, Hsd17b3, Fshb, and Pomc were also mediated by 5ngL(-1) norgestrel or higher during different exposure periods. Taken together, the overall results imply that the transcriptional changes in zebrafish eleutheroembryos may pose a potential effect on embryonic development, in particular in the brain and gonadogenesis. Environ Toxicol Chem 2015;34:112-119. (c) 2014 SETAC
部门归属LMB
关键词Gene Transcription Hypothalamic-pituitary-adrenal Axis Hypothalamic-pituitary-gonadal Axis Norgestrel Zebrafish
学科领域Environmental Sciences & Ecology ; Toxicology
URL查看原文
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/14904
专题中科院海洋生物资源可持续利用重点实验室
通讯作者guang-guo.ying@gig.ac.cn
作者单位1.[Liang, Yan-Qiu
2.Huang, Guo-Yong
3.Ying, Guang-Guo
4.Liu, Shuang-Shuang
5.Jiang, Yu-Xia
6.Liu, Shan
7.Peng, Feng-jiao] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China
8.[Liu, Shan] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,et al. A TIME-COURSE TRANSCRIPTIONAL KINETICS OF THE HYPOTHALAMIC-PITUITARY-GONADAL AND HYPOTHALAMIC-PITUITARY-ADRENAL AXES IN ZEBRAFISH ELEUTHEROEMBRYOS AFTER EXPOSURE TO NORGESTREL[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2015,34(1):112-119.
APA Liang, Yan-Qiu.,Huang, Guo-Yong.,Ying, Guang-Guo.,Liu, Shuang-Shuang.,Jiang, Yu-Xia.,...&guang-guo.ying@gig.ac.cn.(2015).A TIME-COURSE TRANSCRIPTIONAL KINETICS OF THE HYPOTHALAMIC-PITUITARY-GONADAL AND HYPOTHALAMIC-PITUITARY-ADRENAL AXES IN ZEBRAFISH ELEUTHEROEMBRYOS AFTER EXPOSURE TO NORGESTREL.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,34(1),112-119.
MLA Liang, Yan-Qiu,et al."A TIME-COURSE TRANSCRIPTIONAL KINETICS OF THE HYPOTHALAMIC-PITUITARY-GONADAL AND HYPOTHALAMIC-PITUITARY-ADRENAL AXES IN ZEBRAFISH ELEUTHEROEMBRYOS AFTER EXPOSURE TO NORGESTREL".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 34.1(2015):112-119.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
A TIME-COURSE TRANSC(821KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。