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DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata
Li, Yaoguo; Huang, Xiande; Guan, Yunyan; Shi, Yu; Zhang, Hua; He, Maoxian; hmx@scsio.ac.cn
2015
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume45Issue:2Pages:912-918
AbstractGalectin is one important member of pattern recognition proteins that plays a pivotal role in regulating innate immune response of invertebrates. In this study, we cloned the promoter sequence of a tandem-repeat galectin from the pearl oyster Pinctada fucata (P. fucata). The quantitative real-time PCR analysis revealed that galectin mRNA expression in mantle tissues were firstly up-regulated from time points of 2 h-24 h, and then down-regulated from time points of 24 h-168 h after mantle injury. The genome methylation level of mantle tissue was inversely related to galectin mRNA expression (Pearson correlation: -0.554, P: 0.154). The "CpG4-6" methylation level in promoter region of galectin was significant positive correlated with the mRNA expression (Pearson correlation: 0313, P: 0.049). The results indicated that galectin gene may be involved in immune response in mantle wound healing process of P. fucata, and DNA methylation may be a regulation factor of gene expression. (C) 2015 Elsevier Ltd. All rights reserved.
Department[Li, Yaoguo; Huang, Xiande; Guan, Yunyan; Shi, Yu; Zhang, Hua; He, Maoxian] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, Guangzhou 510301, Guangdong, Peoples R China; [Li, Yaoguo; Zhang, Hua] Univ Chinese Acad Sci, Beijing, Peoples R China ; LTO
KeywordPinctada Fucata Mantle Injury Galectin Promoter Region Dna Methylation
Subject AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/14943
Collection热带海洋环境国家重点实验室(LTO)
Corresponding Authorhmx@scsio.ac.cn
Recommended Citation
GB/T 7714
Li, Yaoguo,Huang, Xiande,Guan, Yunyan,et al. DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata[J]. FISH & SHELLFISH IMMUNOLOGY,2015,45(2):912-918.
APA Li, Yaoguo.,Huang, Xiande.,Guan, Yunyan.,Shi, Yu.,Zhang, Hua.,...&hmx@scsio.ac.cn.(2015).DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata.FISH & SHELLFISH IMMUNOLOGY,45(2),912-918.
MLA Li, Yaoguo,et al."DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata".FISH & SHELLFISH IMMUNOLOGY 45.2(2015):912-918.
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