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Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages
Tang, Hao; Ge, Hui; Chen, Zhi-Bin; Luo, Xiong-Ming; Su, Feng-Juan; Liang, Yan-Bing; Li, Zhen-Yu; Wu, Jing-Guo; Yang, Qing; Zeng, Li-Jin; Ma, Zhong-Fu; kyrintang@163.com; gehui2009gh@126.com; psyczb@aliyun.com; luoxm163@sina.com; jisufengjuan@163.com; xuyw8591@126.com; leezhenyu99@163.com; wjg114500@163.com; yangqin804@163.com; 164555182@qq.com; mazhongfu05@sohu.com
2015
Source PublicationMARINE DRUGS
Volume13Issue:9Pages:5593-5605
Subtype1660-3397
AbstractMicrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found that micrometam C significantly suppressed the migration of immune cells in tail-cutting-induced inflammation in transgenic zebrafish and reduced lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) in both zebrafish and macrophages. In addition, micrometam C also restored LPS-induced reduction of endogenous antioxidants, such as catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD). The protective effects of micrometam C were in parallel to its inhibition of NADPH oxidase and nuclear factor-kappa-binding (NF-B) activity. Thus, the present results demonstrate that micrometam C protects against LPS-induced inflammation possibly through its antioxidant property.
Department[Tang, Hao; Chen, Zhi-Bin; Liang, Yan-Bing; Li, Zhen-Yu; Wu, Jing-Guo; Yang, Qing; Zeng, Li-Jin; Ma, Zhong-Fu] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gen Internal Med, Guangzhou 510080, Guangdong, Peoples R China; [Ge, Hui] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Hlth Care Clin, Guangzhou 510080, Guangdong, Peoples R China; [Luo, Xiong-Ming] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Su, Feng-Juan] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou 510080, Guangdong, Peoples R China ; LTO
KeywordMicrometam c Inflammatory Zebrafish Nf-b Nadph Oxidase
Subject AreaPharmacology & Pharmacy
Indexed BySCI
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15032
Collection热带海洋环境国家重点实验室(LTO)
Corresponding Authorkyrintang@163.com; gehui2009gh@126.com; psyczb@aliyun.com; luoxm163@sina.com; jisufengjuan@163.com; xuyw8591@126.com; leezhenyu99@163.com; wjg114500@163.com; yangqin804@163.com; 164555182@qq.com; mazhongfu05@sohu.com
Recommended Citation
GB/T 7714
Tang, Hao,Ge, Hui,Chen, Zhi-Bin,et al. Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages[J]. MARINE DRUGS,2015,13(9):5593-5605.
APA Tang, Hao.,Ge, Hui.,Chen, Zhi-Bin.,Luo, Xiong-Ming.,Su, Feng-Juan.,...&mazhongfu05@sohu.com.(2015).Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages.MARINE DRUGS,13(9),5593-5605.
MLA Tang, Hao,et al."Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages".MARINE DRUGS 13.9(2015):5593-5605.
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