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Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium
Zhao, Bi-Qing; Peng, Shuai; He, Wei-Jun; Liu, Yong-Hong; Wang, Jun-Feng; Zhou, Xiao-Jiang; Wang, JF; Zhou, XJ (reprint author), Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.; Zhou, XJ (reprint author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.; Zhou, XJ (reprint author), Peking Union Med Coll, Beijing 100050, Peoples R China.; Wang, JF (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China.
2016
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume26Issue:20Pages:4996-4999
AbstractFive new tigliane diterpene esters (1-5), highly oxygenated tetracyclic diterpenoid carbon skeleton, together with three known analogues (6-8) were isolated from the leaves of Croton tiglium. Extensive NMR and mass spectroscopic analysis were used to elucidate their structures. Most of the isolated compounds were tested for their cytotoxic and antitubercular activities. Among them, the cytotoxic activities of these tigliane-type diterpenes strongly depend on the species of the tumor cells. Especially, these bioactivity compounds showed strong cytotoxic activities against the K562 cell line, and their inhibition effects were close to the positive control Taxol. Furthermore, compounds 1, 2, 6, and 7 showed potent antitubercular activities with MIC values of 19.5, 20.9, 20.5, and 13.4 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
Department[Zhao, Bi-Qing; Peng, Shuai; He, Wei-Jun; Wang, Jun-Feng; Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China; [Zhou, Xiao-Jiang] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; [Zhou, Xiao-Jiang] Peking Union Med Coll, Beijing 100050, Peoples R China; [He, Wei-Jun; Liu, Yong-Hong; Wang, Jun-Feng] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China ; LMB
KeywordCroton Tiglium Tiglianes Diterpenoids Antitubercular Activity Cytotoxicity
Subject AreaPharmacology & Pharmacy ; Chemistry
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15274
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorWang, JF; Zhou, XJ (reprint author), Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.; Zhou, XJ (reprint author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.; Zhou, XJ (reprint author), Peking Union Med Coll, Beijing 100050, Peoples R China.; Wang, JF (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Zhao, Bi-Qing,Peng, Shuai,He, Wei-Jun,et al. Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(20):4996-4999.
APA Zhao, Bi-Qing.,Peng, Shuai.,He, Wei-Jun.,Liu, Yong-Hong.,Wang, Jun-Feng.,...&Wang, JF .(2016).Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(20),4996-4999.
MLA Zhao, Bi-Qing,et al."Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.20(2016):4996-4999.
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