Synthesis and antibacterial evaluation of hamacanthin B analogues
Kim, Ahhyun; Kim, Min Jeong; Noh, Tae Hwan; Hong, Jongki; Liu, Yonghong; Wei, Xiaoyi; Jung, Jee H.; Jung, JH (reprint author), Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea.
2016
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号26期号:20页码:5013-5017
摘要Hamacanthins are a class of antibacterial bisindole alkaloids isolated from marine sponges. Based on structure-activity relationships and in silico MRSA PK binding analysis of these bisindole alkaloids, the authors designed new hamacanthin B derivatives and evaluated their antibacterial activities against drug-resistant pathogens. Racemates of the synthetic products were resolved into their enantiomers by chiral separation using a cellulose column, and antibacterial activities were compared. Unsaturation of the central heterocyclic ring structure and bromine substitution at the indole moiety were found to enhance the antibacterial activities of hamacanthin B analogues. (C) 2016 Elsevier Ltd. All rights reserved.
部门归属[Kim, Ahhyun; Kim, Min Jeong; Noh, Tae Hwan; Jung, Jee H.] Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea; [Hong, Jongki] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea; [Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou 510650, Guangdong, Peoples R China; [Wei, Xiaoyi] Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China ; LMB
关键词Hamacanthin b Bisindole Alkaloids Mrsa Pyruvate Kinase Chiral Separation
学科领域Pharmacology & Pharmacy ; Chemistry
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15275
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Jung, JH (reprint author), Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea.
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Kim, Ahhyun,Kim, Min Jeong,Noh, Tae Hwan,et al. Synthesis and antibacterial evaluation of hamacanthin B analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(20):5013-5017.
APA Kim, Ahhyun.,Kim, Min Jeong.,Noh, Tae Hwan.,Hong, Jongki.,Liu, Yonghong.,...&Jung, JH .(2016).Synthesis and antibacterial evaluation of hamacanthin B analogues.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(20),5013-5017.
MLA Kim, Ahhyun,et al."Synthesis and antibacterial evaluation of hamacanthin B analogues".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.20(2016):5013-5017.
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