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A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66
Huang, Huiming; Li, Huayue; Qiu, Yanhong; Hou, Lukuan; Ju, Jianhua; Li, Wenli; Li, WL (reprint author), Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China.; Li, WL (reprint author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China.
2016
Source PublicationMARINE DRUGS
Volume14Issue:10Pages:184
AbstractThe wblA(so) gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the wblA(so) mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50 value of 19.4 g/mL, while compounds 1 and 2 showed null activity up to 100 g/mL.
Department[Huang, Huiming; Li, Huayue; Qiu, Yanhong; Hou, Lukuan; Li, Wenli] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China; [Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,South China Sea, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Li, Wenli] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China ; LMB
KeywordDeepsea-derived Streptomyces Dioic Acid Wbla(So)
Subject AreaPharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15281
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorLi, WL (reprint author), Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China.; Li, WL (reprint author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China.
Recommended Citation
GB/T 7714
Huang, Huiming,Li, Huayue,Qiu, Yanhong,et al. A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66[J]. MARINE DRUGS,2016,14(10):184.
APA Huang, Huiming.,Li, Huayue.,Qiu, Yanhong.,Hou, Lukuan.,Ju, Jianhua.,...&Li, WL .(2016).A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66.MARINE DRUGS,14(10),184.
MLA Huang, Huiming,et al."A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66".MARINE DRUGS 14.10(2016):184.
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