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Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001
Chen, Shengtian; Wang, Junfeng; Lin, Xiuping; Zhao, Bingxin; Wei, Xiaoyi; Li, Guangqiang; Kaliaperumal, Kumaravel; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Liu, Juan; Xu, Shihai; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Matria Med,CAS Key Lab T, Guangzhou 510301, Guangdong, Peoples R China.; Xu, SH (reprint author), Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China.
2016
Source PublicationORGANIC LETTERS
Volume18Issue:15Pages:3650-3653
AbstractThree dimeric nitrophenyl trans-epoxyamides, chrysamides A-C (1-3), were obtained from the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Their structures were characterized by spectroscopic analysis, electronic circular dichroism computations, and X-ray single-crystal diffraction analysis. Notably, compound 1 possesses a novel centrosymmetric dimer skeleton featuring an unprecedented 7-oxa-2,5-diazabicyclo[2.2.1]heptane ring system, which represents the first example of dimeric nitrophenyl trans-epoxyamide in nature. Compound 3 suppresses the production of proinflammatory cytokine interleukin-17. A possible biosynthetic pathway of 1-3 was proposed.
Department[Chen, Shengtian; Wang, Junfeng; Lin, Xiuping; Kaliaperumal, Kumaravel; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Liu, Juan; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Matria Med,CAS Key Lab T, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Shengtian; Zhao, Bingxin; Li, Guangqiang; Xu, Shihai] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China; [Wei, Xiaoyi] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Conservat & Sustainable Utilizat, Guangzhou 510650, Guangdong, Peoples R China ; LMB
Subject AreaChemistry
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15306
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorLiu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Matria Med,CAS Key Lab T, Guangzhou 510301, Guangdong, Peoples R China.; Xu, SH (reprint author), Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Chen, Shengtian,Wang, Junfeng,Lin, Xiuping,et al. Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001[J]. ORGANIC LETTERS,2016,18(15):3650-3653.
APA Chen, Shengtian.,Wang, Junfeng.,Lin, Xiuping.,Zhao, Bingxin.,Wei, Xiaoyi.,...&Xu, SH .(2016).Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001.ORGANIC LETTERS,18(15),3650-3653.
MLA Chen, Shengtian,et al."Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001".ORGANIC LETTERS 18.15(2016):3650-3653.
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