The unique chemistry and biology of the piericidins
Zhou, Xuefeng; Fenical, William; Fenical, W (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 9500 Gilman Dr, La Jolla, CA 92093 USA.
2016
发表期刊JOURNAL OF ANTIBIOTICS
卷号69期号:8页码:582-593
摘要The piericidin family of microbial metabolites features a 4-pyridinol core linked with a methylated polyketide side chain. Piericidins are exclusively produced by actinomycetes, especially members of the genus Streptomyces. The close structural similarity with coenzyme Q renders the piericidins important NADH-ubiquinone oxidoreductase (complex I) inhibitors in the mitochondria! electron transport chain. Because of the significant activities of the piericidins, which include insecticidal, antimicrobial and antitumor effects, total syntheses of the piericidins were developed using various synthetic strategies. The biosynthetic origin of this class has also been the subject of investigation. This review covers the isolation and structure determination of the natural piericidins, their chemical modification, the total syntheses of natural and unnatural analogs, their biosynthesis, and reported biological activities together with structure-activity relationships. Given the fundamental biology of this class of metabolites, the piericidin family will likely continue to attract attention as biological probes of important biosynthetic processes.
部门归属[Zhou, Xuefeng; Fenical, William] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 9500 Gilman Dr, La Jolla, CA 92093 USA; [Zhou, Xuefeng] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China ; LMB
学科领域Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15376
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Fenical, W (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 9500 Gilman Dr, La Jolla, CA 92093 USA.
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Zhou, Xuefeng,Fenical, William,Fenical, W . The unique chemistry and biology of the piericidins[J]. JOURNAL OF ANTIBIOTICS,2016,69(8):582-593.
APA Zhou, Xuefeng,Fenical, William,&Fenical, W .(2016).The unique chemistry and biology of the piericidins.JOURNAL OF ANTIBIOTICS,69(8),582-593.
MLA Zhou, Xuefeng,et al."The unique chemistry and biology of the piericidins".JOURNAL OF ANTIBIOTICS 69.8(2016):582-593.
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