SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
The unique chemistry and biology of the piericidins
Zhou, Xuefeng; Fenical, William; Fenical, W (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 9500 Gilman Dr, La Jolla, CA 92093 USA.
2016
Source PublicationJOURNAL OF ANTIBIOTICS
Volume69Issue:8Pages:582-593
AbstractThe piericidin family of microbial metabolites features a 4-pyridinol core linked with a methylated polyketide side chain. Piericidins are exclusively produced by actinomycetes, especially members of the genus Streptomyces. The close structural similarity with coenzyme Q renders the piericidins important NADH-ubiquinone oxidoreductase (complex I) inhibitors in the mitochondria! electron transport chain. Because of the significant activities of the piericidins, which include insecticidal, antimicrobial and antitumor effects, total syntheses of the piericidins were developed using various synthetic strategies. The biosynthetic origin of this class has also been the subject of investigation. This review covers the isolation and structure determination of the natural piericidins, their chemical modification, the total syntheses of natural and unnatural analogs, their biosynthesis, and reported biological activities together with structure-activity relationships. Given the fundamental biology of this class of metabolites, the piericidin family will likely continue to attract attention as biological probes of important biosynthetic processes.
Department[Zhou, Xuefeng; Fenical, William] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 9500 Gilman Dr, La Jolla, CA 92093 USA; [Zhou, Xuefeng] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China ; LMB
Subject AreaBiotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15376
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorFenical, W (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 9500 Gilman Dr, La Jolla, CA 92093 USA.
Recommended Citation
GB/T 7714
Zhou, Xuefeng,Fenical, William,Fenical, W . The unique chemistry and biology of the piericidins[J]. JOURNAL OF ANTIBIOTICS,2016,69(8):582-593.
APA Zhou, Xuefeng,Fenical, William,&Fenical, W .(2016).The unique chemistry and biology of the piericidins.JOURNAL OF ANTIBIOTICS,69(8),582-593.
MLA Zhou, Xuefeng,et al."The unique chemistry and biology of the piericidins".JOURNAL OF ANTIBIOTICS 69.8(2016):582-593.
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