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Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway
Wang, Jie; Wang, Qiao-Li; Nong, Xu-Hua; Zhang, Xiao-Yong; Xu, Xin-Ya; Qi, Shu-Hua; Wang, Yi-Fei; Qi, SH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
2016
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
Volume783Pages:47-55
AbstractOxalicumone A (POA1), a novel dihydrothiophene-condensed sulfur chromone isolated from the marine fungus Penicillium oxalicum SCSGAF 0023, showed cytotoxicity against several cancer cells previously. In this study, its anti-cancer activity and underlying mechanism of this action were investigated in leukemia cells like KG-1a, HL60, U937, and K562. The results showed that POA1 inhibited dose-/time-dependently cell growth and induced apoptosis in leukemia cells. Also, POA1 caused cleavages of caspase-3, 8, 9 and PARP1, loss of mitochondrial membrane potential, up-regulations of phosphorylated p38 and JNK, and activation of endoplasmic reticulum stress (ER stress). Furthermore, 4-PBA (an ER stress inhibitor) but not SP600125 and SB203580 (JNK and p38 inhibitor, respectively) could largely inhibit POA1-induced growth suppression. Additionally, 4-PBA obstructed mitochondrial depolarization and cleavage of PARP1. These data suggested that ER stress pathway might be an important mediator in POA1-induced apoptosis. In conclusion, POA1 may have antitumor effects in leukemia cells through the induction of ER stress pathway. (C) 2016 Elsevier B.V. All rights reserved.
Department[Wang, Jie; Nong, Xu-Hua; Zhang, Xiao-Yong; Xu, Xin-Ya; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Qiao-Li; Wang, Yi-Fei] Jinan Univ, Natl Engn Res Ctr Genet Med, Guangzhou Jinan Biomed Res & Dev Ctr, 601 West Huangpu Rd, Guangzhou 510632, Guangdong, Peoples R China; [Qi, Shu-Hua] South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510301, Guangdong, Peoples R China ; LMB
KeywordOxalicumone a Mechanism Of Action Apoptosis Er Stress Mapks Leukemia Cell
Subject AreaPharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15381
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorQi, SH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Jie,Wang, Qiao-Li,Nong, Xu-Hua,et al. Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2016,783:47-55.
APA Wang, Jie.,Wang, Qiao-Li.,Nong, Xu-Hua.,Zhang, Xiao-Yong.,Xu, Xin-Ya.,...&Qi, SH .(2016).Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway.EUROPEAN JOURNAL OF PHARMACOLOGY,783,47-55.
MLA Wang, Jie,et al."Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway".EUROPEAN JOURNAL OF PHARMACOLOGY 783(2016):47-55.
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