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Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger
Fang, Wei; Lin, Xiuping; Wang, Jianjiao; Liu, Yonghong; Tao, Huaming; Zhou, Xuefeng; Zhou, XF (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China.; Tao, HM (reprint author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
2016
Source PublicationMOLECULES
Volume21Issue:7Pages:941
AbstractBis-naphtho--pyrones (BNPs) are an important group of aromatic polyketides derived from fungi, and asperpyrone-type BNPs are produced primarily by Aspergillus species. The fungal strain Aspergillus niger SCSIO Jcsw6F30, isolated from a marine alga, Sargassum sp., and identified according to its morphological traits and the internal transcribed spacer (ITS) region sequence, was studied for BNPs secondary metabolisms. After HPLC/MS analysis of crude extract of the fermentation broth, 11 asperpyrone-type BNPs were obtained directly and quickly by chromatographic separation in the extract, and those isolated asperpyrone-type BNPs were structurally identified by NMR and MS analyses. All of the BNPs showed weak cytotoxicities against 10 human tumor cells (IC50 > 30 M). However, three of them, aurasperone F (3), aurasperone C (6) and asperpyrone A (8), exhibited obvious COX-2-inhibitory activities, with the IC50 values being 11.1, 4.2, and 6.4 M, respectively. This is the first time the COX-2-inhibitory activities of BNPs have been reported.
Department[Fang, Wei] Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China; [Lin, Xiuping; Liu, Yonghong; Zhou, Xuefeng] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Jianjiao] Wuhan Univ Sci & Technol, Dept Pharm, Coll Med, Wuhan 430065, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China ; LMB
KeywordBis-naphtho--pyrones Aspergillus Niger Cox-2-inhibitory Hplc Ms
Subject AreaChemistry
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15384
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorZhou, XF (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China.; Tao, HM (reprint author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Fang, Wei,Lin, Xiuping,Wang, Jianjiao,et al. Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger[J]. MOLECULES,2016,21(7):941.
APA Fang, Wei.,Lin, Xiuping.,Wang, Jianjiao.,Liu, Yonghong.,Tao, Huaming.,...&Tao, HM .(2016).Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger.MOLECULES,21(7),941.
MLA Fang, Wei,et al."Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger".MOLECULES 21.7(2016):941.
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