Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration
Feng, J-B; Huang, D-R; Zhong, M.; Liu, P.; Dong, J-D; Feng, JB (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Appl Marine Biol Guangdong Prov, Key Lab Trop Marine Bioresources & Ecol LMB, Guangzhou 510301, Guangdong, Peoples R China.; Feng, JB (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Chinese Acad Sci LAMB, Sanya, Peoples R China.
2016
发表期刊JOURNAL OF FISH DISEASES
卷号39期号:7页码:833-843
摘要Pharmacokinetics and elimination of florfenicol and florfenicol amine in grouper held in sea water at 23.3 +/- 0.8 degrees C were studied using HPLC method after they were given a single peroral dose of florfenicol at 24mgkg(-1) body weight. Florfenicol was rapidly absorbed from intestine and distributed extensively to all the tissues examined. The maximum concentrations (C-max, gg(-1) or gmL(-1)) in plasma and tissues were observed at 2-6h (the time to reach maximum concentration, T-max) except for bile (T-max=24h) and were in the order of intestine (52.02 +/- 25.07)>bile (49.41 +/- 28.16)>gill (45.12 +/- 11.10)>plasma (28.28 +/- 5.43)>liver (21.97 +/- 12.08)>muscle (21.63 +/- 6.12)>kidney (20.88 +/- 11.28)>skin (19.10 +/- 5.88). The drug distribution level was higher in plasma than in extravascular tissues except for bile, based on the ratios of the area under concentration-time curve between tissue and plasma (AUC(tissue/plasma)). The elimination of florfenicol was rapid in fish, and the corresponding half-lives (T-1/2) in the order of magnitude were bile (13.92h)>muscle or liver (12.31h)>skin (11.77h)>plasma (11.57)>gill (11.04h)> intestine (10.55h)>kidney (10.05h). The delayed T-max, lower C-max and longer T-1/2 for florfenicol amine compared with florfenicol were measured in grouper.
部门归属[Feng, J-B; Zhong, M.; Dong, J-D] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Appl Marine Biol Guangdong Prov, Key Lab Trop Marine Bioresources & Ecol LMB, Guangzhou 510301, Guangdong, Peoples R China; [Feng, J-B; Dong, J-D] Chinese Acad Sci, South China Sea Inst Oceanol, Chinese Acad Sci LAMB, Sanya, Peoples R China; [Feng, J-B; Dong, J-D] Chinese Acad Sci, South China Sea Inst Oceanol, Trop Marine Biol Res Stn Hainan, Sanya, Peoples R China; [Huang, D-R] South Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China; [Liu, P.] South China Agr Univ, Coll Anim Sci, Dept Aquaculture, Guangzhou, Guangdong, Peoples R China ; LMB
关键词Distribution Elimination Florfenicol Florfenicol Amine Grouper Pharmacokinetics
学科领域Fisheries ; Marine & Freshwater Biology ; Veterinary Sciences
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15391
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Feng, JB (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Appl Marine Biol Guangdong Prov, Key Lab Trop Marine Bioresources & Ecol LMB, Guangzhou 510301, Guangdong, Peoples R China.; Feng, JB (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Chinese Acad Sci LAMB, Sanya, Peoples R China.
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GB/T 7714
Feng, J-B,Huang, D-R,Zhong, M.,et al. Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration[J]. JOURNAL OF FISH DISEASES,2016,39(7):833-843.
APA Feng, J-B.,Huang, D-R.,Zhong, M..,Liu, P..,Dong, J-D.,...&Feng, JB .(2016).Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration.JOURNAL OF FISH DISEASES,39(7),833-843.
MLA Feng, J-B,et al."Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration".JOURNAL OF FISH DISEASES 39.7(2016):833-843.
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