Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020
Liang, Xiao; Zhang, Xiao-Yong; Nong, Xu-Hua; Wang, Jie; Huang, Zhong-Hui; Qi, Shu-Hua; Qi, SH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
2016
发表期刊TETRAHEDRON
卷号72期号:22页码:3092-3097
摘要Eight new linear peptides, simplicilliumtides A-H (1-8) were isolated from a culture broth of the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were determined by Marfey's method. Compounds 1-2 are linear tetrapeptides possessing a 2-aminobenzoic acid residue. Compounds 3-8 are acetylated linear tri- or di-peptides. Their antifouling, antibacterial, cytotoxic, and acetylcholinesterase inhibiting activities were evaluated. Compound 4 showed strong antifouling activity against Bugula neritina larvae settlement. And 1, 5, 7 and 8 showed weak cytotoxicity towards human leukemia HL-60 or K562 cell line. (C) 2016 Elsevier Ltd. All rights reserved.
部门归属[Liang, Xiao; Zhang, Xiao-Yong; Nong, Xu-Hua; Wang, Jie; Huang, Zhong-Hui; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Liang, Xiao; Huang, Zhong-Hui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; LMB
关键词Deep-sea-derived Fungus Simplicillium Obclavatum Linear Peptide Antifouling Cytotoxicity
学科领域Chemistry
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15397
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Qi, SH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
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GB/T 7714
Liang, Xiao,Zhang, Xiao-Yong,Nong, Xu-Hua,et al. Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020[J]. TETRAHEDRON,2016,72(22):3092-3097.
APA Liang, Xiao.,Zhang, Xiao-Yong.,Nong, Xu-Hua.,Wang, Jie.,Huang, Zhong-Hui.,...&Qi, SH .(2016).Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020.TETRAHEDRON,72(22),3092-3097.
MLA Liang, Xiao,et al."Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020".TETRAHEDRON 72.22(2016):3092-3097.
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