SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
Zhao, Min; Cheng, Shimiao; Yuan, Weiping; Xi, Yiyuan; Li, Xiubao; Dong, Jianyong; Huang, Kexin; Gustafson, Kirk R.; Yan, Pengcheng; Yan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.; Gustafson, KR; Yan, PC (reprint author), NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA.
2016
Source PublicationMARINE DRUGS
Volume14Issue:6Pages:111
AbstractTen new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R, 8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 mu M.
Department[Zhao, Min; Yuan, Weiping; Xi, Yiyuan; Dong, Jianyong; Huang, Kexin; Yan, Pengcheng] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China; [Cheng, Shimiao] Wenzhou Med Univ, Affiliated Hosp 5, Lishui 323000, Peoples R China; [Li, Xiubao] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Gustafson, Kirk R.; Yan, Pengcheng] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA ; LMB
KeywordSoft Coral Lobophytum Crassum Cembrane-based Diterpenes No Inhibition
Subject AreaPharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15405
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorYan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.; Gustafson, KR; Yan, PC (reprint author), NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA.
Recommended Citation
GB/T 7714
Zhao, Min,Cheng, Shimiao,Yuan, Weiping,et al. Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum[J]. MARINE DRUGS,2016,14(6):111.
APA Zhao, Min.,Cheng, Shimiao.,Yuan, Weiping.,Xi, Yiyuan.,Li, Xiubao.,...&Yan, PC .(2016).Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.MARINE DRUGS,14(6),111.
MLA Zhao, Min,et al."Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum".MARINE DRUGS 14.6(2016):111.
Files in This Item:
File Name/Size DocType Version Access License
Cembranoids from a C(2747KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.