Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection
Cai, Jia; Yu, Dapeng; Wei, Shina; Tang, Jufen; Lu, Yishan; Wu, Zaohe; Qin, Qiwei; Jian, Jichang; Jian, JC (reprint author), Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Peoples R China.; Qin, QW (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
2016
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号52页码:2016-09-15
摘要Apoptosis plays vital roles in many physiological process and immune response. BOK is one of the central regulators in apoptosis. In this study, a new BOX homolog (Ec-BOK) was cloned and characterized from Orange-spotted grouper, Epinephelus coioides. Ec-BOK encoded a 210 amino acid peptides which shared 97% identity to Stegastes partitus BOK protein, contained four BH domains and one transmembrane region. Ec-BOK widely expressed in all analyzed tissues with the higher expressions in kidney and spleen. Its expression level was up-regulated after SGIV infection in vitro. Further analysis revealed that over expression of Ec-BOK inhibited viral genes transcriptions and virus replication in fish cell. Our findings suggested that Ec-BOK might play a role in the immune response against virus. (C) 2016 Elsevier Ltd. All rights reserved.
部门归属[Cai, Jia; Yu, Dapeng; Tang, Jufen; Lu, Yishan; Jian, Jichang] Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Peoples R China; [Cai, Jia; Yu, Dapeng; Tang, Jufen; Lu, Yishan; Wu, Zaohe; Jian, Jichang] Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China; [Cai, Jia; Yu, Dapeng; Tang, Jufen; Lu, Yishan; Wu, Zaohe; Jian, Jichang] Guangdong Key Lab Control Dis Aquat Econ Anim, Zhanjiang 524088, Peoples R China; [Wei, Shina; Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China ; LMB
关键词Epinephelus Coioides Bok Singapore Grouper Iridovirus (Sgiv) Viral Gene Viral Replication
学科领域Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15421
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Jian, JC (reprint author), Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Peoples R China.; Qin, QW (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
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Cai, Jia,Yu, Dapeng,Wei, Shina,et al. Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection[J]. FISH & SHELLFISH IMMUNOLOGY,2016,52:2016-09-15.
APA Cai, Jia.,Yu, Dapeng.,Wei, Shina.,Tang, Jufen.,Lu, Yishan.,...&Qin, QW .(2016).Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection.FISH & SHELLFISH IMMUNOLOGY,52,2016-09-15.
MLA Cai, Jia,et al."Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection".FISH & SHELLFISH IMMUNOLOGY 52(2016):2016-09-15.
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