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Cryptic prophages as targets for drug development
Wang, Xiaoxue; Wood, Thomas K.; Wood, TK (reprint author), Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA.; Wang, XX (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bio resources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.
2016
Source PublicationDRUG RESISTANCE UPDATES
Volume27Pages:30-38
AbstractBacterial chromosomes may contain up to 20% phage DNA that encodes diverse proteins ranging from those for photosynthesis to those for autoimmunity; hence, phages contribute greatly to the metabolic potential of pathogens. Active prophages carrying genes encoding virulence factors and antibiotic resistance can be excised from the host chromosome to form active phages and are transmissible among different bacterial hosts upon SOS responses. Cryptic prophages are artifacts of mutagenesis in which lysogenic phage are captured in the bacterial chromosome: they may excise but they do not form active phage particles or lyse their captors. Hence, cryptic prophages are relatively permanent reservoirs of genes, many of which benefit pathogens, in ways we are just beginning to discern. Here we explore the role of active prophage- and cryptic prophage-derived proteins in terms of (i) virulence, (ii) antibiotic resistance, and (iii) antibiotic tolerance; antibiotic tolerance occurs as a result of the non-heritable phenotype of dormancy which is a result of activation of toxins of toxin/antitoxin loci that are frequently encoded in cryptic prophages. Therefore, cryptic prophages are promising targets for drug development. (C) 2016 The Authors. Published by Elsevier Ltd.
Department[Wang, Xiaoxue] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Wood, Thomas K.] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA; [Wood, Thomas K.] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
KeywordCryptic Prophage Antibiotic Resistance Antibiotic Tolerance Horizontal Gene Transfer Toxin-antitoxin System
Subject AreaPharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15456
Collection中科院边缘海地质重点实验室
Corresponding AuthorWood, TK (reprint author), Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA.; Wang, XX (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bio resources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Xiaoxue,Wood, Thomas K.,Wood, TK ,et al. Cryptic prophages as targets for drug development[J]. DRUG RESISTANCE UPDATES,2016,27:30-38.
APA Wang, Xiaoxue,Wood, Thomas K.,Wood, TK ,&Wang, XX .(2016).Cryptic prophages as targets for drug development.DRUG RESISTANCE UPDATES,27,30-38.
MLA Wang, Xiaoxue,et al."Cryptic prophages as targets for drug development".DRUG RESISTANCE UPDATES 27(2016):30-38.
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