Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879
Wang, Junfeng; He, Weijun; Huang, Xiaolong; Tian, Xinpeng; Liao, Shengrong; Yang, Bin; Wang, Fazuo; Zhou, Xiaojiang; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China.
2016
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号64期号:14页码:2910-2916
摘要Phytopathogenic fungi remain a continuous and huge threat in the agricultural fields. The agrochemical industry has made great development of the use of microbial natural products, which has been regarded as an effective strategy against phytopathogenic fungi. Antifungal bioassay-directed fractionation was used to isolate two new oxepine-containing alkaloids (1 and 2), two new 4-aryl-quinolin-2-one alkaloids (3 and 4), and four new prenylated xanthones (5-8) from the deep-sea-derived fungus Aspergillus versicolor SCSIO 05879. Extensive NMR spectroscopic analysis, quantum mechanical calculations, and X-ray single-crystal diffraction were used to elucidate their structures, including their absolute configurations. Versicoloids A and B, versicone A, and cottoquinazoline A showed antifungal activities against three phytopathogenic fungi. The antifungal activities of these bioactive compounds strongly depend on the fungal species. Especially versicoloids A and B showed strong fungicidal effect (AEC of 1.6 mu g/mL) against Colletotrichum acutatum, compared with that of the positive control cydoheximide (MIC of 6.4 mu g/mL). The results of antifungal experiments indicated that versicoloids A and B may be regarded as candidate agents of antifungal agro chemicals.
部门归属[Wang, Junfeng; He, Weijun; Tian, Xinpeng; Liao, Shengrong; Yang, Bin; Wang, Fazuo; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [He, Weijun; Zhou, Xiaojiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China; [Huang, Xiaolong] Hainan Univ, Coll Agr, Haikou 571101, Peoples R China ; LMB
关键词Deep-sea-derived Aspergillus Versicolor Ecd Calculations Oxepine Phytopathogenic Fungi Antifungal Activities
学科领域Agriculture ; Chemistry ; Food Science & Technology
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15464
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China.
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Wang, Junfeng,He, Weijun,Huang, Xiaolong,et al. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(14):2910-2916.
APA Wang, Junfeng.,He, Weijun.,Huang, Xiaolong.,Tian, Xinpeng.,Liao, Shengrong.,...&Liu, YH .(2016).Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,64(14),2910-2916.
MLA Wang, Junfeng,et al."Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64.14(2016):2910-2916.
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