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Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea
Yuan, Weiping; Cheng, Shimiao; Fu, Weitao; Zhao, Min; Li, Xiubao; Cai, Yuepiao; Dong, Jianyong; Huang, Kexin; Gustafson, Kirk R.; Yan, Pengcheng; Yan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China.; Gustafson, KR; Yan, PC (reprint author), NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA.
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:4Pages:1124-1131
AbstractNineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and the two new cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcydopent-2-en-1-one (4) and (S)-4-hydroxy-5-methylene-2,3dimethyl-4-pentylcydopent-2-en-1-one (5), were isolated from a South China Sea collection of the soft coral Sinularia verruca. Eleven previously described marine metabolites (7-15, 18, and 19) were also obtained as well as three new EtOH-adduct artifacts (6, 16, and 17). The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 4, 5, and 16 showed protection against the cytopathic effects of HIV-1 infection with EC50 values of 5.8-34 mu M, and 4, 6, and 16 exhibited inhibition against LPS-induced NO production with IC50 values of 24-28 mu M.
Department[Yuan, Weiping; Fu, Weitao; Zhao, Min; Cai, Yuepiao; Dong, Jianyong; Huang, Kexin; Yan, Pengcheng] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China; [Cheng, Shimiao] Wenzhou Med Univ, Affiliated Hosp 5, Lishui 323000, Zhejiang, Peoples R China; [Li, Xiubao] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Gustafson, Kirk R.; Yan, Pengcheng] NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA ; LMB
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15469
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorYan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China.; Gustafson, KR; Yan, PC (reprint author), NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA.
Recommended Citation
GB/T 7714
Yuan, Weiping,Cheng, Shimiao,Fu, Weitao,et al. Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):1124-1131.
APA Yuan, Weiping.,Cheng, Shimiao.,Fu, Weitao.,Zhao, Min.,Li, Xiubao.,...&Yan, PC .(2016).Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.JOURNAL OF NATURAL PRODUCTS,79(4),1124-1131.
MLA Yuan, Weiping,et al."Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea".JOURNAL OF NATURAL PRODUCTS 79.4(2016):1124-1131.
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