Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea
Yuan, Weiping; Cheng, Shimiao; Fu, Weitao; Zhao, Min; Li, Xiubao; Cai, Yuepiao; Dong, Jianyong; Huang, Kexin; Gustafson, Kirk R.; Yan, Pengcheng; Yan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China.; Gustafson, KR; Yan, PC (reprint author), NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA.
2016
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号79期号:4页码:1124-1131
摘要Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and the two new cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcydopent-2-en-1-one (4) and (S)-4-hydroxy-5-methylene-2,3dimethyl-4-pentylcydopent-2-en-1-one (5), were isolated from a South China Sea collection of the soft coral Sinularia verruca. Eleven previously described marine metabolites (7-15, 18, and 19) were also obtained as well as three new EtOH-adduct artifacts (6, 16, and 17). The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 4, 5, and 16 showed protection against the cytopathic effects of HIV-1 infection with EC50 values of 5.8-34 mu M, and 4, 6, and 16 exhibited inhibition against LPS-induced NO production with IC50 values of 24-28 mu M.
部门归属[Yuan, Weiping; Fu, Weitao; Zhao, Min; Cai, Yuepiao; Dong, Jianyong; Huang, Kexin; Yan, Pengcheng] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China; [Cheng, Shimiao] Wenzhou Med Univ, Affiliated Hosp 5, Lishui 323000, Zhejiang, Peoples R China; [Li, Xiubao] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Gustafson, Kirk R.; Yan, Pengcheng] NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA ; LMB
学科领域Plant Sciences ; Pharmacology & Pharmacy
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15469
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Yan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China.; Gustafson, KR; Yan, PC (reprint author), NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA.
推荐引用方式
GB/T 7714
Yuan, Weiping,Cheng, Shimiao,Fu, Weitao,et al. Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):1124-1131.
APA Yuan, Weiping.,Cheng, Shimiao.,Fu, Weitao.,Zhao, Min.,Li, Xiubao.,...&Yan, PC .(2016).Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.JOURNAL OF NATURAL PRODUCTS,79(4),1124-1131.
MLA Yuan, Weiping,et al."Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea".JOURNAL OF NATURAL PRODUCTS 79.4(2016):1124-1131.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Structurally Diverse(1188KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。