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Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)
Wang, Junfeng; Qin, Xiaochu; Chen, Zhiyun; Ju, Zhiran; He, Weijun; Tan, Yehui; Zhou, Xiaojiang; Tu, Zhengchao; Lu, Fangguo; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China.; Lu, FG (reprint author), Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
2016
Source PublicationPHYTOCHEMISTRY LETTERS
Volume15Pages:13-15
AbstractTwo new anthraquinones, 1,3-dihydroxy-5-methoxy-6-methoxymethyl-2-methyl-9,10-anthraquinone (1) and 1,3-dihydroxy-5-methoxy-2,6-bismethoxymethyl-9,10-anthraquinone (2), together with ten known anthraquinone derivatives (3-12), three coumarin derivatives (13-15), and 6-gingerol (16) were isolated from the barks of Morinda citrifolia (Noni) collected in the Yongxing island of Xisha. The structures of compounds (1-16) were determined on the basis of extensive spectroscopic analyses, as well as by comparison with literature reports. The new compounds 1 and 2 were tested for their antiviral, cytotoxic, and antibacterial activities. In the primary bioassays, compounds 1 and 2 displayed weak antiH1N1 activity with IC50 values of 66.1 and 10.5 mu M, respectively. In addition, compound 2 showed weak anti-H3N2 activity with IC50 value of 11.5 mu M, and had weak antimicrobial activity against Staphylococcus aureus with MIC value of 24.5 mu M. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Department[Wang, Junfeng; Chen, Zhiyun; Ju, Zhiran; He, Weijun; Tan, Yehui; Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China; [Qin, Xiaochu; Tu, Zhengchao] Chinese Acad Sci, Lab Mol Engn, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Qin, Xiaochu; Tu, Zhengchao] Chinese Acad Sci, Lab Nat Prod Synth, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [He, Weijun; Zhou, Xiaojiang; Lu, Fangguo] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China ; LMB
KeywordMorinda Citrifolia Anthraquinone Antiviral Activity Antimicrobial Activity
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15489
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorLiu, YH (reprint author), Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China.; Lu, FG (reprint author), Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Junfeng,Qin, Xiaochu,Chen, Zhiyun,et al. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)[J]. PHYTOCHEMISTRY LETTERS,2016,15:13-15.
APA Wang, Junfeng.,Qin, Xiaochu.,Chen, Zhiyun.,Ju, Zhiran.,He, Weijun.,...&Lu, FG .(2016).Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni).PHYTOCHEMISTRY LETTERS,15,13-15.
MLA Wang, Junfeng,et al."Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)".PHYTOCHEMISTRY LETTERS 15(2016):13-15.
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