Soil-borne reservoirs of antibiotic-resistant bacteria are established following therapeutic treatment of dairy calves
Liu, Jinxin; Zhao, Zhe; Orfe, Lisa; Subbiah, Murugan; Call, Douglas R.; Call, DR (reprint author), Washington State Univ, Paul G Allen Sch Global Anim Hlth, Pullman, WA 99164 USA.
2016
发表期刊ENVIRONMENTAL MICROBIOLOGY
卷号18期号:2页码:557-564
摘要We determined if antibiotics residues that are excreted from treated animals can contribute to persistence of resistant bacteria in agricultural environments. Administration of ceftiofur, a third-generation cephalosporin, resulted in a approximate to 3 log increase in ceftiofur-resistant Escherichia coli found in the faeces and pen soils by day 10 (P=0.005). This resistant population quickly subsided in faeces, but was sustained in the pen soil (approximate to 4.5 log bacteriag(-1)) throughout the trial (1 month). Florfenicol treatment resulted in a similar pattern although the loss of florfenicol-resistant E.coli was slower for faeces and remained stable at approximate to 6 log bacteriag(-1) in the soil. Calves were treated in pens where eGFP-labelled E.coli were present in the bedding (approximate to 2 logg(-1)) resulting in amplification of the eGFP E.coli population approximate to 2.1 log more than eGFP E.coli populations in pens with untreated calves (day 4; P<0.005). Excreted residues accounted for >10-fold greater contribution to the bedding reservoir compared with shedding of resistant bacteria in faeces. Treatment with therapeutic doses of ceftiofur or florfenicol resulted in 2-3 logg(-1) more bacteria than the estimated ID50 (2.83 CFUg(-1)), consistent with a soil-borne reservoir emerging after antibiotic treatment that can contribute to the long-term persistence of antibiotic resistance in animal agriculture.
部门归属[Liu, Jinxin; Zhao, Zhe; Orfe, Lisa; Subbiah, Murugan; Call, Douglas R.] Washington State Univ, Paul G Allen Sch Global Anim Hlth, Pullman, WA 99164 USA; [Zhao, Zhe] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; LMB
学科领域Microbiology
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15499
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Call, DR (reprint author), Washington State Univ, Paul G Allen Sch Global Anim Hlth, Pullman, WA 99164 USA.
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Liu, Jinxin,Zhao, Zhe,Orfe, Lisa,et al. Soil-borne reservoirs of antibiotic-resistant bacteria are established following therapeutic treatment of dairy calves[J]. ENVIRONMENTAL MICROBIOLOGY,2016,18(2):557-564.
APA Liu, Jinxin,Zhao, Zhe,Orfe, Lisa,Subbiah, Murugan,Call, Douglas R.,&Call, DR .(2016).Soil-borne reservoirs of antibiotic-resistant bacteria are established following therapeutic treatment of dairy calves.ENVIRONMENTAL MICROBIOLOGY,18(2),557-564.
MLA Liu, Jinxin,et al."Soil-borne reservoirs of antibiotic-resistant bacteria are established following therapeutic treatment of dairy calves".ENVIRONMENTAL MICROBIOLOGY 18.2(2016):557-564.
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