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New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel
Ju, Zhi-ran; Qin, Xiaochu; Lin, Xiu-ping; Wang, Jun-feng; Kaliyaperumal, Kumaravel; Tian, Yong-qi; Liu, Juan; Liu, Fen; Tu, Zhengchao; Xu, Shi-hai; Liu, Yonghong; Tu, ZC (reprint author), Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China.
2016
Source PublicationNATURAL PRODUCT RESEARCH
Volume30Issue:2Pages:192-198
AbstractTwo new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1-7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12M.
Department[Ju, Zhi-ran; Liu, Fen; Xu, Shi-hai] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China; [Ju, Zhi-ran; Lin, Xiu-ping; Wang, Jun-feng; Kaliyaperumal, Kumaravel; Tian, Yong-qi; Liu, Juan; Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; [Qin, Xiaochu; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China; [Qin, Xiaochu; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Nat Prod Synth, Guangzhou 510530, Guangdong, Peoples R China ; LMB
KeywordEndophytic Fungus BotryoSphaeria Sp Scsio Kcf6 Cox-2 Inhibitory Activity
Subject AreaChemistry ; Pharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15509
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorTu, ZC (reprint author), Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Ju, Zhi-ran,Qin, Xiaochu,Lin, Xiu-ping,et al. New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel[J]. NATURAL PRODUCT RESEARCH,2016,30(2):192-198.
APA Ju, Zhi-ran.,Qin, Xiaochu.,Lin, Xiu-ping.,Wang, Jun-feng.,Kaliyaperumal, Kumaravel.,...&Tu, ZC .(2016).New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel.NATURAL PRODUCT RESEARCH,30(2),192-198.
MLA Ju, Zhi-ran,et al."New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel".NATURAL PRODUCT RESEARCH 30.2(2016):192-198.
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