Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30
Zhou, Xuefeng; Fang, Wei; Tan, Suiyi; Lin, Xiuping; Xun, Tianrong; Yang, Bingjie; Liu, Shuwen; Liu, Yonghong; Liu, SW (reprint author), South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.
2016
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号26期号:2页码:361-365
摘要Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3) and D (4), together with six known compounds (1, 2, and 5-8), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C (5) showed the strongest anti-HIV-1 activity with IC50 of 1.4 +/- 0.06 mu M (selectivity index, 11.4), meanwhile aspernigrin C (3) also exhibited potent activity with IC50 of 4.7 +/- 0.4 mu M (selectivity index, 7.5). (C) 2015 Elsevier Ltd. All rights reserved.
部门归属[Zhou, Xuefeng; Lin, Xiuping; Yang, Bingjie; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Fang, Wei] Hubei Acad Agr Sci, Ctr Biopesticide Engn Res, Wuhan 430064, Peoples R China; [Tan, Suiyi; Xun, Tianrong; Yang, Bingjie; Liu, Shuwen] South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China ; LMB
关键词Aspergillus Niger Aspernigrins Malformin c Hiv-1 Sf162
学科领域Pharmacology & Pharmacy ; Chemistry
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15510
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Liu, SW (reprint author), South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.
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GB/T 7714
Zhou, Xuefeng,Fang, Wei,Tan, Suiyi,et al. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(2):361-365.
APA Zhou, Xuefeng.,Fang, Wei.,Tan, Suiyi.,Lin, Xiuping.,Xun, Tianrong.,...&Liu, SW .(2016).Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(2),361-365.
MLA Zhou, Xuefeng,et al."Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.2(2016):361-365.
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