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Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30
Zhou, Xuefeng; Fang, Wei; Tan, Suiyi; Lin, Xiuping; Xun, Tianrong; Yang, Bingjie; Liu, Shuwen; Liu, Yonghong; Liu, SW (reprint author), South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.
2016
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume26Issue:2Pages:361-365
AbstractTwo new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3) and D (4), together with six known compounds (1, 2, and 5-8), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C (5) showed the strongest anti-HIV-1 activity with IC50 of 1.4 +/- 0.06 mu M (selectivity index, 11.4), meanwhile aspernigrin C (3) also exhibited potent activity with IC50 of 4.7 +/- 0.4 mu M (selectivity index, 7.5). (C) 2015 Elsevier Ltd. All rights reserved.
Department[Zhou, Xuefeng; Lin, Xiuping; Yang, Bingjie; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Fang, Wei] Hubei Acad Agr Sci, Ctr Biopesticide Engn Res, Wuhan 430064, Peoples R China; [Tan, Suiyi; Xun, Tianrong; Yang, Bingjie; Liu, Shuwen] South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China ; LMB
KeywordAspergillus Niger Aspernigrins Malformin c Hiv-1 Sf162
Subject AreaPharmacology & Pharmacy ; Chemistry
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15510
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorLiu, SW (reprint author), South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Zhou, Xuefeng,Fang, Wei,Tan, Suiyi,et al. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(2):361-365.
APA Zhou, Xuefeng.,Fang, Wei.,Tan, Suiyi.,Lin, Xiuping.,Xun, Tianrong.,...&Liu, SW .(2016).Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(2),361-365.
MLA Zhou, Xuefeng,et al."Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.2(2016):361-365.
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