A New Diketopiperazine from the Marine Sponge Callyspongia Species
Yang, Bin; Huang, Jingxia; Lin, Xiuping; Zhang, Yanying; Tao, Huaming; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China.
2016
发表期刊RECORDS OF NATURAL PRODUCTS
卷号10期号:1页码:117-121
摘要Chemical investigation of the sponge Callyspongia sp. from the South China Sea afforded one new diketopiperazine, cyclo-(R-Pro-6-hydroxyl-S-Ile) (1), along with six known diketopiperazines: staphyloamide A (2), cyclo-(S-Pro-S-Phe) (3), cyclo-(R-Pro-R-Phe) (4), cyclo-(S-Pro-R-Leu) (5), cyclo-(S-Pro-R-Ala) (6), cyclo( R-Tyr-R-Phe) (7), and three known tryptophan-derived alkaloids: C-2-alpha-D-mannosylpyranosyl-tryptophan (8), (1R, 3S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (9), and (1R, 3R)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxylic acid (10). The structures were determined on the basis of NMR and MS analysis, and the absolute configuration was determined by comparison of the optical rotation with the known compounds. This is the first report of compounds 1, 2, 8-10 from the sponge Callyspongia. Cyclo-(S-Pro-R-Leu) (5), and cyclo-(S-Pro-R-Ala) (6) exhibited antifouling activity against cyprid larvae of the barnacle with the LC50 values of 3.5 mu g/cm(2) and 6.0 mu g/cm(2), respectively.
部门归属[Yang, Bin; Lin, Xiuping; Zhang, Yanying; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China; [Huang, Jingxia] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China ; LMB
关键词CallySp.ngia Sp. Diketopiperazine Chemical Constituents Antifouling Activity
学科领域Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15528
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China.
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Yang, Bin,Huang, Jingxia,Lin, Xiuping,et al. A New Diketopiperazine from the Marine Sponge Callyspongia Species[J]. RECORDS OF NATURAL PRODUCTS,2016,10(1):117-121.
APA Yang, Bin.,Huang, Jingxia.,Lin, Xiuping.,Zhang, Yanying.,Tao, Huaming.,...&Liu, YH .(2016).A New Diketopiperazine from the Marine Sponge Callyspongia Species.RECORDS OF NATURAL PRODUCTS,10(1),117-121.
MLA Yang, Bin,et al."A New Diketopiperazine from the Marine Sponge Callyspongia Species".RECORDS OF NATURAL PRODUCTS 10.1(2016):117-121.
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