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A New Diketopiperazine from the Marine Sponge Callyspongia Species
Yang, Bin; Huang, Jingxia; Lin, Xiuping; Zhang, Yanying; Tao, Huaming; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China.
2016
Source PublicationRECORDS OF NATURAL PRODUCTS
Volume10Issue:1Pages:117-121
AbstractChemical investigation of the sponge Callyspongia sp. from the South China Sea afforded one new diketopiperazine, cyclo-(R-Pro-6-hydroxyl-S-Ile) (1), along with six known diketopiperazines: staphyloamide A (2), cyclo-(S-Pro-S-Phe) (3), cyclo-(R-Pro-R-Phe) (4), cyclo-(S-Pro-R-Leu) (5), cyclo-(S-Pro-R-Ala) (6), cyclo( R-Tyr-R-Phe) (7), and three known tryptophan-derived alkaloids: C-2-alpha-D-mannosylpyranosyl-tryptophan (8), (1R, 3S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (9), and (1R, 3R)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxylic acid (10). The structures were determined on the basis of NMR and MS analysis, and the absolute configuration was determined by comparison of the optical rotation with the known compounds. This is the first report of compounds 1, 2, 8-10 from the sponge Callyspongia. Cyclo-(S-Pro-R-Leu) (5), and cyclo-(S-Pro-R-Ala) (6) exhibited antifouling activity against cyprid larvae of the barnacle with the LC50 values of 3.5 mu g/cm(2) and 6.0 mu g/cm(2), respectively.
Department[Yang, Bin; Lin, Xiuping; Zhang, Yanying; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China; [Huang, Jingxia] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China ; LMB
KeywordCallySp.ngia Sp. Diketopiperazine Chemical Constituents Antifouling Activity
Subject AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15528
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorLiu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Yang, Bin,Huang, Jingxia,Lin, Xiuping,et al. A New Diketopiperazine from the Marine Sponge Callyspongia Species[J]. RECORDS OF NATURAL PRODUCTS,2016,10(1):117-121.
APA Yang, Bin.,Huang, Jingxia.,Lin, Xiuping.,Zhang, Yanying.,Tao, Huaming.,...&Liu, YH .(2016).A New Diketopiperazine from the Marine Sponge Callyspongia Species.RECORDS OF NATURAL PRODUCTS,10(1),117-121.
MLA Yang, Bin,et al."A New Diketopiperazine from the Marine Sponge Callyspongia Species".RECORDS OF NATURAL PRODUCTS 10.1(2016):117-121.
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