Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp SCSIO XWS02F40
Tian, Yong-Qi; Lin, Xiu-Ping; Wang, Zhen; Zhou, Xue-Feng; Qin, Xiao-Chu; Kaliyaperumal, Kumaravel; Zhang, Tian-Yu; Tu, Zheng-Chao; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China.
2016
发表期刊MOLECULES
卷号21期号:1页码:-
摘要Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge-derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1-7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC50 values of 6.2 +/- 0.08 and 8.9 +/- 0.3 M, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC50 value of 3.5 +/- 1.3 M.
部门归属[Tian, Yong-Qi; Lin, Xiu-Ping; Zhou, Xue-Feng; Kaliyaperumal, Kumaravel; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China; [Tian, Yong-Qi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wang, Zhen; Qin, Xiao-Chu; Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China; [Wang, Zhen; Qin, Xiao-Chu; Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Nat Prod Synth, Guangzhou 510530, Guangdong, Peoples R China; [Zhang, Tian-Yu] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China ; LMB
关键词Sponge-derived Fungus Asteltoxins Antiviral (H1n1 And H3n2) Activity
学科领域Chemistry
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/15530
专题中科院海洋生物资源可持续利用重点实验室
通讯作者Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China.
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Tian, Yong-Qi,Lin, Xiu-Ping,Wang, Zhen,et al. Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp SCSIO XWS02F40[J]. MOLECULES,2016,21(1):-.
APA Tian, Yong-Qi.,Lin, Xiu-Ping.,Wang, Zhen.,Zhou, Xue-Feng.,Qin, Xiao-Chu.,...&Liu, YH .(2016).Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp SCSIO XWS02F40.MOLECULES,21(1),-.
MLA Tian, Yong-Qi,et al."Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp SCSIO XWS02F40".MOLECULES 21.1(2016):-.
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