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Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702
Wang, Junfeng; Wei, Xiaoyi; Qin, Xiaochu; Tian, Xinpeng; Liao, Li; Li, Kemin; Zhou, Xuefeng; Yang, Xianwen; Wang, Fazuo; Zhang, Tianyu; Tu, Zhengchao; Chen, Bo; Liu, Yonghong; Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:1Pages:59-65
AbstractFive new highly oxygenated alpha-pyrone merosesquiterpenoids, ochraceopones A-E (1-5), together with one new double bond isomer of asteltoxin, isoasteltoxin (6), and two known asteltoxin derivatives, asteltoxin (7) and asteltoxin B (8), were isolated from an Antarctic soil-derived fungus, Aspergillus ochraceopetaliformis SCSIO 05702. Their structures were determined through extensive spectroscopic analysis, CD spectra, quantum mechanical calculations, and X-ray single-crystal diffraction. Ochraceopones A-D (1-4) are the first examples of alpha-pyrone merosesquiterpenoids possessing a linear tetracyclic carbon skeleton, which has not been previously described. All the isolated compounds were tested for their antiviral, cytotoxic, antibacterial, and antitubercular activities. Among these compounds, ochraceopone A (1), isoasteltoxin (6), and asteltoxin (7) exhibited antiviral activities against the H1N1 and H3N2 influenza viruses with IC50 values of >20.0/12.2 +/- 4.10, 0.23 +/- 0.05/0.66 +/- 0.09, and 0.54 +/- 0.06/0.84 +/- 0.02 mu M, respectively. A possible biosynthetic pathway for ochraceopones A-E (1-5) was proposed.
Department[Wang, Junfeng; Tian, Xinpeng; Zhou, Xuefeng; Yang, Xianwen; Wang, Fazuo; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Wei, Xiaoyi] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China; [Qin, Xiaochu; Li, Kemin; Zhang, Tianyu; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China; [Qin, Xiaochu; Li, Kemin; Zhang, Tianyu; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Nat Prod Synth, Guangzhou 510530, Guangdong, Peoples R China; [Liao, Li; Chen, Bo] Polar Res Inst China, SOA Key Lab Polar Sci, Shanghai 200136, Peoples R China ; LMB
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15534
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorLiu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Junfeng,Wei, Xiaoyi,Qin, Xiaochu,et al. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):59-65.
APA Wang, Junfeng.,Wei, Xiaoyi.,Qin, Xiaochu.,Tian, Xinpeng.,Liao, Li.,...&Liu, YH .(2016).Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702.JOURNAL OF NATURAL PRODUCTS,79(1),59-65.
MLA Wang, Junfeng,et al."Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702".JOURNAL OF NATURAL PRODUCTS 79.1(2016):59-65.
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