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Nahuoic Acids B-E, Polyhydroxy Polyketides from the Marine-Derived Streptomyces sp SCSGAA 0027
Nong, Xu-Hua; Zhang, Xiao-Yong; Xu, Xin-Ya; Wang, Jie; Qi, Shu-Hua; Qi, SH (reprint author), Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol,Guangdo K, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:1Pages:141-148
AbstractFour new polyol polyketides containing a decalin ring, nahuoic acids B-E (1-4), together with a known analogue, nahuoic acid A (5), possessing an unprecedented carbon skeleton, were isolated from a culture broth of the marine-derived Streptomyces sp. SCSGAA 0027. Their structures were determined by detailed analysis of spectroscopic data and chemical transformations including acetonide formation and Moshers ester method. Compounds 1-5 showed weak antibiofilm activity against Shewanella onedensis MR-1 biofilm. This is the first series of analogues of the novel selective SETD8 inhibitor nahuoic acid A.
Department[Nong, Xu-Hua; Zhang, Xiao-Yong; Xu, Xin-Ya; Wang, Jie; Qi, Shu-Hua] Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol,Guangdo K, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China ; LMB
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/15535
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding AuthorQi, SH (reprint author), Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol,Guangdo K, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
Recommended Citation
GB/T 7714
Nong, Xu-Hua,Zhang, Xiao-Yong,Xu, Xin-Ya,et al. Nahuoic Acids B-E, Polyhydroxy Polyketides from the Marine-Derived Streptomyces sp SCSGAA 0027[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):141-148.
APA Nong, Xu-Hua,Zhang, Xiao-Yong,Xu, Xin-Ya,Wang, Jie,Qi, Shu-Hua,&Qi, SH .(2016).Nahuoic Acids B-E, Polyhydroxy Polyketides from the Marine-Derived Streptomyces sp SCSGAA 0027.JOURNAL OF NATURAL PRODUCTS,79(1),141-148.
MLA Nong, Xu-Hua,et al."Nahuoic Acids B-E, Polyhydroxy Polyketides from the Marine-Derived Streptomyces sp SCSGAA 0027".JOURNAL OF NATURAL PRODUCTS 79.1(2016):141-148.
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