Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7
He, WJ; Zhou, XJ; Qin, XC; Mai, YX; Lin, XP; Liao, SR; Yang, B; Zhang, TY; Tu, ZC; Wang, JF; Liu, YH; wangjunfeng@scsio.ac.cn; yonghongliu@scsio.ac.cn
2017
发表期刊NATURAL PRODUCT RESEARCH
卷号31期号:5页码:604-609
摘要Fifteen compounds, including six quinone/hydroquinone meroter-penoids, purpurogemutantin (1), macrophorin A (2), 4'-oxomacrophorin (3), 7-deacetoxyyanuthone A (4), 2,3-hydro-deacetoxyyanuthone A (5), 22-deacetylyanuthone A (6), anicequol (7), three roquefortine derivatives, roquefortine C (8), (16S)-hydroxyroquefortine C (9), (16R)-hydroxyroquefortine C (10), dihydroresorcylide (11), nectriapyrone (12), together with three fatty acid derivatives, methyl linoleate (13), phospholipase A 2 (14), methyl elaidate (15), were isolated from the sponge-derived fungus Gliomastix sp. ZSDS1-F7 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analyses. Among these compounds, compounds 1-3 and 5-7 showed significant in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4 and HL60 cell lines, with IC50 values ranging from 0.19 to 35.4 mu M. And compounds 2-4 exhibited antitubercular activity with IC 50 values of 22.1, 2.44 and 17.5 mu M, respectively. Furthermore, compound 7 had anti-enterovirus 71 activity with MIC value of 17.8 mu M. To the best of our knowledge, this is the first report to product two quinone/hydroquinone meroterpenoids skeletons (linear skeleton and drimane skeleton) from the same fungal strain. [GRAPHICS] .
部门归属[He, Wei-Jun; Mai, Yong-Xin; Lin, Xiu-Ping; Liao, Sheng-Rong; Yang, Bin; Wang, Jun-Feng; Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou, Guangdong, Peoples R China; [He, Wei-Jun; Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha, Hunan, Peoples R China; [Qin, Xiao-Chu; Zhang, Tianyu; Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China; [Liu, Yonghong] South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China
关键词Sponge-derived Fungus Phakellia Fusca Thiele Meroterpenoid Roquefortine Cytotoxic Activity Antitubercular Activity Anti-enterovirus 71 Activity
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16213
专题中科院海洋生物资源可持续利用重点实验室
通讯作者wangjunfeng@scsio.ac.cn; yonghongliu@scsio.ac.cn
推荐引用方式
GB/T 7714
He, WJ,Zhou, XJ,Qin, XC,et al. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7[J]. NATURAL PRODUCT RESEARCH,2017,31(5):604-609.
APA He, WJ.,Zhou, XJ.,Qin, XC.,Mai, YX.,Lin, XP.,...&yonghongliu@scsio.ac.cn.(2017).Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7.NATURAL PRODUCT RESEARCH,31(5),604-609.
MLA He, WJ,et al."Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7".NATURAL PRODUCT RESEARCH 31.5(2017):604-609.
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