Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019
Cui, H; Ding, M; Huang, DN; Zhang, ZR; Liu, HT; Huang, HB; She, ZG; huanghb@scsio.ac.cn; cesshzhg@mail.sysu.edu.cn
2017
发表期刊RSC ADVANCES
卷号7期号:33页码:20128-20134
摘要Seven new compounds: diaporchromanones A-D (1-4), (-)-phomopsichin A (5a), (+)-phomopsichin B (6a), and (-)-diaporchromone A (7), along with the known (+)-phomopsichin A (5b) and (-)-phomopsichin B (6b) were isolated from an endophytic fungus Diaporthe phaseolorum SKS019. The structures of the new compounds, including their absolute configurations, were determined on the basis of HRESIMS and NMR spectroscopic data, and experimental ECD and Rh-2(OCOCF3)(4) induced CD spectra analyses. Diaporchromanone A (1)/B (2), and C (3)/D (4) are two pairs of 3-epimers, and their structures possessing 3-substituted-chroman-4-one skeleton are rarely found in natural sources. (-)-Phomopsichin A (5a) and (+)-phomopsichin B (6a) are enantiomers of (+)-phomopsichin A (5b) and (-)-phomopsichin B (6b), respectively. All of the isolates were evaluated for their inhibitory effects against osteoclastogenesis in the RAW 264.7 cell line using luciferase reporter gene assays. Compounds 3-6b exhibited moderate inhibitory effects on osteoclastogenesis by suppressing the receptor activator of NF-kappa B by ligand-induced NF-kappa B activation.
部门归属[Cui, Hui; Ding, Meng; Zhang, Zhengrui; Liu, Huiting; She, Zhigang] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China; [Huang, Dane] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China; [Huang, Hongbo] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16220
专题中科院海洋生物资源可持续利用重点实验室
通讯作者huanghb@scsio.ac.cn; cesshzhg@mail.sysu.edu.cn
推荐引用方式
GB/T 7714
Cui, H,Ding, M,Huang, DN,et al. Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019[J]. RSC ADVANCES,2017,7(33):20128-20134.
APA Cui, H.,Ding, M.,Huang, DN.,Zhang, ZR.,Liu, HT.,...&cesshzhg@mail.sysu.edu.cn.(2017).Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019.RSC ADVANCES,7(33),20128-20134.
MLA Cui, H,et al."Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019".RSC ADVANCES 7.33(2017):20128-20134.
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