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Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019
Cui, H; Ding, M; Huang, DN; Zhang, ZR; Liu, HT; Huang, HB; She, ZG; huanghb@scsio.ac.cn; cesshzhg@mail.sysu.edu.cn
2017
Source PublicationRSC ADVANCES
Volume7Issue:33Pages:20128-20134
AbstractSeven new compounds: diaporchromanones A-D (1-4), (-)-phomopsichin A (5a), (+)-phomopsichin B (6a), and (-)-diaporchromone A (7), along with the known (+)-phomopsichin A (5b) and (-)-phomopsichin B (6b) were isolated from an endophytic fungus Diaporthe phaseolorum SKS019. The structures of the new compounds, including their absolute configurations, were determined on the basis of HRESIMS and NMR spectroscopic data, and experimental ECD and Rh-2(OCOCF3)(4) induced CD spectra analyses. Diaporchromanone A (1)/B (2), and C (3)/D (4) are two pairs of 3-epimers, and their structures possessing 3-substituted-chroman-4-one skeleton are rarely found in natural sources. (-)-Phomopsichin A (5a) and (+)-phomopsichin B (6a) are enantiomers of (+)-phomopsichin A (5b) and (-)-phomopsichin B (6b), respectively. All of the isolates were evaluated for their inhibitory effects against osteoclastogenesis in the RAW 264.7 cell line using luciferase reporter gene assays. Compounds 3-6b exhibited moderate inhibitory effects on osteoclastogenesis by suppressing the receptor activator of NF-kappa B by ligand-induced NF-kappa B activation.
Department[Cui, Hui; Ding, Meng; Zhang, Zhengrui; Liu, Huiting; She, Zhigang] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China; [Huang, Dane] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China; [Huang, Hongbo] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16220
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorhuanghb@scsio.ac.cn; cesshzhg@mail.sysu.edu.cn
Recommended Citation
GB/T 7714
Cui, H,Ding, M,Huang, DN,et al. Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019[J]. RSC ADVANCES,2017,7(33):20128-20134.
APA Cui, H.,Ding, M.,Huang, DN.,Zhang, ZR.,Liu, HT.,...&cesshzhg@mail.sysu.edu.cn.(2017).Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019.RSC ADVANCES,7(33),20128-20134.
MLA Cui, H,et al."Chroman-4-one and pyrano[4,3-b] chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019".RSC ADVANCES 7.33(2017):20128-20134.
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