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Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01
Luo, XW; Zhou, XF; Lin, XP; Qin, XC; Zhang, TY; Wang, JF; Tu, ZC; Yang, B; Liao, SR; Tian, YQ; Pang, XY; Kaliyaperumal, K; Li, JL; Tao, HM; Liu, YH; taohm@smu.edu.cn
2017
Source PublicationNATURAL PRODUCT RESEARCH
Volume31Issue:16Pages:1958-1962
AbstractEleven diketopiperazine and fumiquinazoline alkaloids (1-11) together with a tetracyclic triterpenoid helvolic acid (12) were obtained from the cultures of a deep-sea derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated. Gliotoxin (3), 12,13-dihydroxy-fumitremorgin C (11) and helvolic acid (12) exhibited very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50 values of <0.03, 2.41 and 0.894M, respectively, which was here reported for the first time. Meanwhile gliotoxin also displayed significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4M, respectively. [GRAPHICS] .
Department[Luo, Xiaowei; Zhou, Xuefeng; Lin, Xiuping; Wang, Junfeng; Yang, Bin; Liao, Shengrong; Tian, Yongqi; Pang, Xiaoyan; Kaliyaperumal, Kumaravel; Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou, Guangdong, Peoples R China; [Luo, Xiaowei; Pang, Xiaoyan] Univ Chinese Acad Sci, Beijing, Peoples R China; [Qin, Xiaochu; Zhang, Tianyu; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Ctr Infect & Immun, Lab Mol Engn, Guangzhou, Guangdong, Peoples R China; [Qin, Xiaochu; Zhang, Tianyu; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Ctr Infect & Immun, Lab Nat Prod Synth,State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China; [Li, Jian Lin] Nantong Univ, Sch Pharm, Nantong, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China; [Liu, Yonghong] South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China
KeywordDeep Sea Fungi ASpergillus Sp Anti-tuberculosis Alkaloids
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16223
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authortaohm@smu.edu.cn
Recommended Citation
GB/T 7714
Luo, XW,Zhou, XF,Lin, XP,et al. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01[J]. NATURAL PRODUCT RESEARCH,2017,31(16):1958-1962.
APA Luo, XW.,Zhou, XF.,Lin, XP.,Qin, XC.,Zhang, TY.,...&taohm@smu.edu.cn.(2017).Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01.NATURAL PRODUCT RESEARCH,31(16),1958-1962.
MLA Luo, XW,et al."Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01".NATURAL PRODUCT RESEARCH 31.16(2017):1958-1962.
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