Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
Xu, XY; Zhang, XY; Nong, XH; Wang, J; Qi, SH; xuxinya@scsio.ac.cn; zhangxiaoyong@scsio.ac.cn; xhnong@scsio.ac.cn; wangjielangjing@126.com; shuhuaqi@scsio.ac.cn
2017
发表期刊MARINE DRUGS
卷号15期号:2页码:43-
摘要Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50 value of 15.6 mu M. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 13.7 and 22.6 mu M, respectively. The NMR data of 6, 8, and 9 were assigned for the first time.
部门归属[Xu, Xinya; Zhang, Xiaoyong; Nong, Xuhua; Wang, Jie; Qi, Shuhua] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
关键词Penicillium Brevicompactum Brevianamide Mycochromenic Acid Derivative Cytotoxicity Antifouling
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16237
专题中科院海洋生物资源可持续利用重点实验室
通讯作者xuxinya@scsio.ac.cn; zhangxiaoyong@scsio.ac.cn; xhnong@scsio.ac.cn; wangjielangjing@126.com; shuhuaqi@scsio.ac.cn
推荐引用方式
GB/T 7714
Xu, XY,Zhang, XY,Nong, XH,et al. Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025[J]. MARINE DRUGS,2017,15(2):43-.
APA Xu, XY.,Zhang, XY.,Nong, XH.,Wang, J.,Qi, SH.,...&shuhuaqi@scsio.ac.cn.(2017).Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025.MARINE DRUGS,15(2),43-.
MLA Xu, XY,et al."Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025".MARINE DRUGS 15.2(2017):43-.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Brevianamides and My(1657KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。