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Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160
Zhang, WJ; Yang, CF; Huang, CS; Zhang, LP; Zhang, HB; Zhang, QB; Yuan, CS; Zhu, YG; Zhang, CS; czhang@scsio.ac.cn
2017
Source PublicationORGANIC LETTERS
Volume19Issue:3Pages:592-595
AbstractPyrazolofluostatins A-C (1-3), three new benzo[a]-fluorenes with an unprecedented carbon skeleton, were obtained from the South China Sea-derived Micromonospora rosaria SCSIO N160. Their structures were elucidated by extensive spectroscopic analyses. The structure of pyrazolofluostatin A (1) was confirmed by X-ray crystallographic analysis. Notably, 1-3 possessed a benzo[cd]indeno[2,1-f]indazol skeleton with a pyrazole-fused 6/5/6/6/5 pentacydic ring system. Pyrazolofluostatin A (I) showed moderate antioxidation activity (EC50 48.6 mu M).
Department[Zhang, Wenjun; Yang, Chunfang; Huang, Chunshuai; Zhang, Liping; Zhang, Haibo; Zhang, Qingbo; Yuan, Cheng-shan; Zhu, Yiguang; Zhang, Changsheng] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Huang, Chunshuai] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; [Zhang, Wenjun] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; [Zhang, Wenjun] Peking Union Med Coll, Beijing 100050, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16238
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorczhang@scsio.ac.cn
Recommended Citation
GB/T 7714
Zhang, WJ,Yang, CF,Huang, CS,et al. Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160[J]. ORGANIC LETTERS,2017,19(3):592-595.
APA Zhang, WJ.,Yang, CF.,Huang, CS.,Zhang, LP.,Zhang, HB.,...&czhang@scsio.ac.cn.(2017).Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160.ORGANIC LETTERS,19(3),592-595.
MLA Zhang, WJ,et al."Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160".ORGANIC LETTERS 19.3(2017):592-595.
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