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Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502
Huang, ZH; Nong, XH; Ren, Z; Wang, J; Zhang, XY; Qi, SH; shuhuaqi@scsio.ac.cn
2017
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume27Issue:4Pages:787-791
AbstractChemical investigation of the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502 resulted in the isolation of three new anthraquinones, aspergilols G-I (1-3), one new diphenyl ether, 4-carbglyceryl-3,3'dihydroxy-5,5'-dimethyldiphenyl ether (4), and one new benzaldehyde derivative, 2,4-dihydroxy-6-(4methoxy-2-oxopentyl)-3-methylbenzaldehyde (5), along with 23 known phenolic compounds (6-28). The structures of new compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of 3 was established by CD spectrum and the modified Mosher method. Compounds 2, 3 and 9 had evident antiviral activity towards HSV-1 with EC50 values of 4.68, 6.25, and 3.12 mu M, respectively. Compounds 15, 18, 20 and 22-24 showed more potent antioxidant activity than L-ascorbic acid with IC50 values of 18.92-52.27 mu M towards DPPH radicals. Comparison of the structures and antioxidant activities of 1-28 suggests that the number of phenolic hydroxyl group that can freely rotate can significantly affect the antioxidant activity of phenolic compounds. In addition, 4, 22-24 and 27 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 1.28, 2.61, 5.48, 1.59, and 3.40 mu g/ml, respectively. (C) 2017 Elsevier Ltd. All rights reserved.
Department[Huang, Zhonghui; Nong, Xuhua; Wang, Jie; Zhang, Xiaoyong; Qi, Shuhua] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Huang, Zhonghui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Ren, Zhe] Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
KeywordAspergillus Versicolor Phenolic Compounds Antioxidant Antiviral Antifouling
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16240
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshuhuaqi@scsio.ac.cn
Recommended Citation
GB/T 7714
Huang, ZH,Nong, XH,Ren, Z,et al. Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(4):787-791.
APA Huang, ZH.,Nong, XH.,Ren, Z.,Wang, J.,Zhang, XY.,...&shuhuaqi@scsio.ac.cn.(2017).Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(4),787-791.
MLA Huang, ZH,et al."Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.4(2017):787-791.
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